The effect of omeprazole on gastric myoelectrical activity and emptying
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概要
- 論文の詳細を見る
Omeprazole, a proton pump inhibitor, is widely used for the treatment of patients with peptic ulcer, gastroesophageal reflux disease and functional dyspepsia (FD), although some studies have demonstrated that omeprazole delays gastric emptying. The purpose of this study was to investigate the efficacy of omeprazole on gastric motility including gastric myoelectrical activity and gastric emptying. This study was performed on 12 healthy volunteers. Gastric motility was evaluated with cutaneously recorded electrogastrography (EGG) and gastric emptying of semi-solid meals using the 13C-acetic acid breath test. EGG and gastric emptying were measured before and after treatment with 20 mg omeprazole orally for 7 days. In the fasting state, the percentage of EGG normogastria increased significantly compared to the baseline. No significant changes were observed in other EGG parameters including the percentage of tachygastria and bradygastria in both fasting and postprandial states, and the power ratios between both before and after ingestion of omeprazole. In addition, administrated omeprazole did not show any significant differences in the gastric emptying parameters such as the half emptying time. We conclude that administration of omeprazole did not affect gastric motility but improved gastric myoelectrical activity. These effects of omeprazole may be one of the mechanisms involved in its efficacy in relieving dyspeptic symptoms in FD patients.
- 2011-08-01
著者
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Kamiya Takeshi
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Shimura Takaya
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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KANEMATSU Takayoshi
Kasugai City Hospital Internal Medicine
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Joh T
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Joh Takashi
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Ebi Masahide
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Mizuno Tatsuo
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Kataoka Hiromi
Department Of Clinical Laboratory Medicine Kochi Medical School
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Mori Yoshinori
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Imaeda Kenro
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Kato Takashi
Department Of Brain Science And Molecular Imaging National Institute For Longevity Sciences
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Joh Takashi
Department Of Internal Medicine And Bioregulation Nagoya City University Medical School
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Hirata Yoshikazu
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Mizushima Takashi
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Shikano Michiko
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Mizoshita Tsutomu
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Kamiya Takeshi
Department Of Applied Physics Faculty Of Engineering University Of Tokyo:(present Address) Departmen
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Tanida Satoshi
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Tanida Satoshi
Department Of Chemical Engineering And Materials Science Doshisha University
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Joh Takashi
名古屋市立大学大学院医学研究科消化器・代謝内科学
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Kataoka Hiromi
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Tanahashi Junji
Intensive Care Unit Kariya General Hospital
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Tanaka Mamoru
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Tanaka Mamoru
Department Of Applied Chemistry Kobe City College Of Technology
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Tanihara Masao
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Murakami Kenji
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Makita Takashi
Dept. Vet. Anat. Yamaguchi Univ.
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Tanida Satoshi
Department Of Experimental Pathology And Tumor Biology Nagoya City University Graduate School Of Med
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Murakami Kenji
Department Of Biosciences School Of Science And Engineering Teikyo University
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TSUKAMOTO Hironobu
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
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Tsukamoto Hironobu
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Sciences
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Kato Takashi
Department Of Brain Science And Molecular Imaging National Center For Geriatrics And Gerontology
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Kato Takashi
Department Of Applied Chemistry Graduate School Of Engineering Nagoya Institute Of Technology
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