Electrical Properties of Colonic Smooth Muscle in Spontaneously Non-Insulin-Dependent Diabetic Rats
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概要
- 論文の詳細を見る
Electrical properties of colonic smooth muscle were investigated in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a model animal for spontaneous non-insulin-dependent diabetes mellitus (NIDDM), and the results were compared with those obtained from the Long-Evans Tokushima Otsuka (LETO) rat, a control of OLETF rat. At experiments (aged 60-80 weeks), blood glucose level was about 171 mg/dl in LETO rats and 370 mg/dl in OLETF rats. Feces in the colon were restricted to the proximal region in LETO rats and distributed widely in the whole colon in OLETF rats. In both LETO and OLETF rats, the circular smooth muscle strips of the isolated distal colon revealed two types of spontaneous electrical response, slow wave and transient hyperpolarization. The resting membrane potential was smaller in OLETF rats than in LETO rats by about 3 mV, but it was not positively related with the blood glucose level. The amplitude of hyperpolarization produced by noradrenaline (NA) was smaller in OLETF rats than in LETO rats. Transmural nerve stimulation evoked a non-adrenergic, non-cholinergic (NANC) inhibitory junction potential (i.j.p.) in both LETO and OLETF rats ; the amplitude of the i.j.p. was smaller in OLETF rats than in LETO rats, while the latency of the i.j.p. was longer in OLETF rats than in LETO rats. Thus, in the distal colon, NIDDM may cause a depolarization of the membrane, an attenuation of NANC inhibitory transmission and a reduction in reactivity of adrenoceptors to NA. These results suggest that the constipation appearing with diabetes mellitus involves dysfunction of both the enteric autonomic nerves and the smooth muscles in the colon.
- 日本平滑筋学会の論文
著者
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Yokoyama Y
Department Of Physiology Nagoya City University School Of Nursing
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Yokoyama Yoshifumi
First Department Of Internal Medicine Nagoya City University School Of Medicine
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Yamamoto Y
Department Of Physiology Nagoya City University School Of Nursing
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KOSHITA Makoto
Department of Physiology, Nagoya City University Medical School
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YAMAMOTO Yoshimichi
Department of Physiology, Nagoya City University School of Nursing
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SUZUKI Hikaru
Department of Physiology, Nagoya City University Medical School
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IMAEDA Kenro
Department of Physiology, Nagoya City University Medical School
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TAKANO Hiromichi
Department of Physiology, Nagoya City University Medical School
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JOH Takashi
Internal Medicine I, Nagoya City University Medical School
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Joh T
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Imaeda Kenro
名古屋市立大学 医学研究科消化器代謝内科学
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Imaeda Kenro
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Yokoyama Yoshifumi
The First Department Of Internal Medicine Nagoya City University Medical School
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Suzuki H
Department Of Physiology Nagoya City University Medical School
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Suzuki Hikaru
Department Of Physiology Nagoya City University Medical School
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Suzuki Hikaru
Department Of Cell Physiology Nagoya City University Medical School
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Yamamoto Yoshimichi
Laboratory Of Physiology Nagoya City University School Of Nursing
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Yamamoto Y
Department Of Physiology Nagoya City University Nursing School
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Yamamoto Yoshimichi
Department Of Civil Engineering
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Suzuki Hikaru
Dep. Of Cell Physiology
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Koshita M
Department Of Physiology Nagoya City University Medical School
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Yamamoto Yoshimichi
Lab. Of Physiology Nagoya City Univ. School Of Nursing
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Takano Hiromichi
Department Of Physiology Ii Kanazawa Medical University
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Suzuki Hikaru
Department Of Cardiology Tokyo Women's Medical University
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Koshita Makoto
Department of Cell Physiology, Graduate School of Medical Sciences, Nagoya City University
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