Neuronal Control of Motility Changes in the Canine Lower Esophageal Sphincter and Stomach in Response to Meal Ingestion
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概要
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Background & Aims : Neuronal control of motility changes in the lower esophageal sphincter (LES), gastric body (GB) and gastric antrum (GA) in response to meal ingestion is not fully understood. The aim of this study was to investigate the neuronal mechanism of the LES and gastric motility response to meal ingestion in conscious dogs. Methods : Dogs fitted with force transducers in the LES, GB and GA were given neuronal antagonists before a meal. Motility was assessed for 10 min after feeding and was compared to results without antagonists. Results : In the LES, atropine inhibited tonic contractions, whereas N^ω-nitro-L-arginine (L-NAME) significantly enhanced tonic contractions initiated by meal ingestion. In the GB, atropine, hexamethonium or L-NAME inhibited receptive relaxation, and the effect of hexamethonium was significantly greater than that of atropine or L-NAME. In the GA, atropine, hexamethonium or naloxone inhibited postprandial phasic contractions, whereas L-NAME tended to enhance phasic contractions. Conclusions : Neuronal control of postprandial motility was clearly different in each region : (1) LES tonic contractions are mainly regulated by muscarinic receptors, (2) nicotinic transmission plays an essential role in receptive relaxation, which also involves muscarinic receptors and nitric oxide, (3) cholinergic nerves and opiate receptors are involved in the occurrence of antral phasic contractions, and (4) endogenous nitric oxide may inhibit postprandial contractions in the LES and GA.
- 日本平滑筋学会の論文
著者
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MOCHIKI ERITO
Department of General Surgical Science, Gunma University Graduate School of Medicine
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Suzuki H
Department Of Physiology Nagoya City University Medical School
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MIZUMOTO AKIYOSHI
Gastrointestinal Laboratory, Institute or Molecular and Cellular Regulation, Gunma University
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ITOH ZEN
Gastrointestinal Laboratory, Institute or Molecular and Cellular Regulation, Gunma University
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Mochiki Erito
Gastrointestinal Research Laboratory, Institute for Molecular and Cellular Regulation, Gunma Univers
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Suzuki Hideki
Gastrointestinal Research Laboratory, Institute for Molecular and Cellular Regulation, Gunma Univers
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Tanaka Toshiyuki
Gastrointestinal Research Laboratory, Institute for Molecular and Cellular Regulation, Gunma Univers
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Itoh Z
Gi Laboratories Institute For Molecular And Cellular Regulation Gunma University
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Mochiki Erito
Department Of General Surgical Science (surgery I) Graduate School Of Medicine Gunma University
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Mochiki Erito
Department Of General Surgical Science Gunma University Graduate School Of Medicine
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Suzuki Hikaru
Dep. Of Cell Physiology
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Mizumoto A
Gi Laboratories Institute For Molecular And Cellular Regulation Gunma University
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Tanaka T
Second Department Of Surgery Gunma University Faculty Of Medicine
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Mochiki Erito
群馬大学 医学系研究科病態総合外科学
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Itoh Zen
Gastrointestinal Laboratories, Institute of Endocrinology, Gunma University
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