Relationship between intraduodenal 5-hydroxytryptamine release and interdigestive contractions in dogs

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概要

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• Background: 5-hydroxytryptamine (5-HT) is released into the intestinal lumen during the fasting state. However, the relationship between the intraduodenal 5-HT and the interdigestive cyclic motor activity in conscious dogs is unclear. Aim: To correlate intraduodenal 5-HT concentrations with the interdigestive gastroduodenal migrating motor complex (MMC). Methods: 6 dogs were implanted with 2 force transducers for recording gastroduodenal contractions and 2 catheters for measuring duodenal volume by a non-absorbable marker perfusion technique. Intraduodenal 5-HT concentrations were determined by high performance liquid chromatography at 5-min intervals. Results: During fasting, gastroduodenal motor activity cycled as the MMC; luminal 5-HT concentrations and total outputs varied cyclically in temporal association with the MMC. Mean 5-HT concentrations peaked during phase II (P<0.05 vs. phase I and III), and 5-HT outputs during phases II or III were greater than during phase I (P<0.05). Exogenous motilin (0.3 μg/kg-hr, IV) stimulated 5-HT release into the duodenal lumen with peak values (P<0.05) during motilin-induced phase II and III. Gastroduodenal motor activity was not altered, however, during exogenous intraduodenal administration of 5-HT (300 ng/mL-min). Conclusions: 5-HT is released cyclically into the duodenal lumen in close temporal association with the MMC, but its physiologic significance in regulation of gastroduodenal motility is unknown.

• 日本平滑筋学会の論文

著者

• MOCHIKI ERITO

  Department of General Surgical Science, Gunma University Graduate School of Medicine

• MOCHIKI Erito

  First Department of Surgery Gunma University

• ITOH Zen

  GI Laboratory, Institute for Molecular and Cellular Regulation, Guma University

• MIZUMOTO Akiyoshi

  GI Laboratories, Institute for Molecular and Cellular Regulation, Gunma University

• Suzuki H

  Department Of Physiology Nagoya City University Medical School

• TANAKA Toshiyuki

  Second Department of Surgery, Gunma University Faculty of Medicine

• HAGA Norihiro

  First Department of Surgery, Gunma University Faculty of Medicine

• SUZUKI Hideki

  First Department of Surgery, Gunma University Faculty of Medicine

• Itoh Z

  Gi Laboratories Institute For Molecular And Cellular Regulation Gunma University

• Haga Norihiro

  First Department Of Surgery Gunma University Faculty Of Medicine

• Mochiki Erito

  Department Of General Surgical Science (surgery I) Graduate School Of Medicine Gunma University

• Mochiki Erito

  Department Of General Surgical Science Gunma University Graduate School Of Medicine

• Suzuki Hikaru

  Dep. Of Cell Physiology

• Mizumoto A

  Gi Laboratories Institute For Molecular And Cellular Regulation Gunma University

• Mizumoto Akiyoshi

  Gi Laboratories Institute For Molecular And Cellular Regulation Gunma University

• Tanaka T

  Second Department Of Surgery Gunma University Faculty Of Medicine

• Mochiki Erito

  群馬大学 医学系研究科病態総合外科学

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