HDL_3 Exerts a More Powerful Antiperoxidative and Protective Effect against Peroxidative Modification of LDL than HDL_2 Does
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概要
- 論文の詳細を見る
The objective of the present study was to establish that HDL3 has a greater antiperoxidative effect on the peroxidative modification of LDL than HDL2 has. The protective influence of HDL subfractions on this form of LDL modification was examined in samples by measuring the concentration of thiobarbituric acid-reactive substance (TBARS), as well as the electrophoresic mobility of LDL. LDL was incubated for 96 hours in phosphate-buffered saline (PBS) alone, without the addition of transition-metal ions or in the presence of PPS and HDL2 or HDL3. All samples were subjected to agarose gel electrophoresis. Both HDL2 and HDL3 significantly inhibited peroxidative modification of LDL, as assessed by electrophoretic mobility, but this effect was much more pronounced with HDL3. HDL3 may play a more important role than HDL2 in the prevention of atherosclerosis in vivo by more effectively inhibiting LDL peroxidation.
- 財団法人 学会誌刊行センターの論文
- 2002-08-01
著者
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Kamiya Takeshi
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Kimura Genjiro
名古屋市立大学 医学研究科心臓･腎高血圧内科学
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KANEMATSU Takayoshi
Kasugai City Hospital Internal Medicine
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SAKUMA Nagahiko
Third Department of Internal Medicine, Nagoya City University Medical School
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OHTE Nobuyuki
Third Department of Internal Medicine, Nagoya City University Medical School
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KUNIMATSU Mitoshi
Second Department of Biochemistry, Nagoya City University Medical School
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Hibino T
Department Of Internal Medicine And Pathophysiology Nagoya City University Graduate School Of Medica
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Hibino Takeshi
Third Department Of Internal Medicine
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Yoshikawa Masae
Third Department Of Internal Medicine Nagoya City University Medical School
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YOSHIKAWA Masae
The Third Department of Internal Medicine
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Sakuma N
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Yoshikawa Masaki
Third Department Of Internal Medicine Nagoya City University Medical School
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Ohte Nobuyuki
The Third Department Of Internal Medicine Nagoya City University
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Kamiya Takeshi
Third Department Of Internal Medicine Nagoya City University Medical School
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Ohte Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Inoue Makoto
Department Of Pharmacognosy Nagoya City University Faculty Of Pharmaceutical Sciences
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Inoue Makoto
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Kimura Genjiro
Third Department Of Internal Medicine And Pathophysiology Nagoya City University Medical School
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Ohte Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Ohte Nobuyuki
Department Of Internal Medicine And Pathophysiology Nagoya City University Graduate School Of Medica
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Ohte Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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KUNIMATSU MITOSHI
Department of Biochemistry, Nagoya Women's University
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