Evaluation of Fatty Acid β-Oxidation in Patients With Prior Myocardial Infarction in Relation to Myocardial Blood Flow, Total Oxidative Metabolism, and Left Ventricular Wall Motion
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概要
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Background Fatty acid metabolism in patients with myocardial infarction (MI) who undergo coronary reperfusion has not been fully elucidated and was investigated in the present study using positron emission tomography. Methods and Results The clearance rate constant of ^<11>C-acetate (acetate-K_<mono>) and that of ^<11>C-palmitate (palmitate-K_<mono>) from the myocardium were calculated using a monoexponential equation in 14 patients with MI. A total of 155 regions of interest were classified based on coefficient of determination (R^2) values of monoexponential curves for ^<11>C-palmitate clearance : well fitted regions (R_2≥0.5) and poorly fitted regions (R^2<0.5). Regional relative myocardial blood flow calculated from the initial distribution of ^<11>C-acetate and left ventricular (LV) wall motion were also evaluated. Peak ^<11>C-palmitate uptake (14,434±3.052vs12,016±3,088 counts/s, p<0.001) and percent clearance during acquisition (38.2±10.1vs23.6±11.4%, p<0.001) were significantly greater in the well fitted regions (n=111) than in the poorly fitted regions (n=44). Acetate-K_<mono> was significantly higher in the former than in the latter (0.0641±0.0099vs0.0476±0.0103min^<-1>, p<0.001). LV wall motion and regional relative blood flow were also significantly greater in the former regions. Palmitate-K_<mono> in the well fitted regions was significantly higher in normal LV wall motion areas than in hypokinesis areas (0.0363±0.0062vs0.0274±0.0057min^<-1>, p<0.001) Conclusions Maintenance of myocardial fatty acid β-oxidation with better myocardial blood flow is substantial in the preservation of total myocardial oxidative metabolism and LV wall motion in patients with MI. The finding that the early-phase clearance of ^<11>C-palmitate is fitted with a monoexponential curve may provide important information in the evaluation of myocardial fatty acid β-oxidation.
- 社団法人日本循環器学会の論文
- 2005-11-20
著者
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Kimura Genjiro
名古屋市立大学 医学研究科心臓･腎高血圧内科学
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Kimura Genjiro
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Ohte Nobuyuki
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medi
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Narita Hitomi
Department of Internal Medicine and Pathophysiology, Nagoya City University Gradutae School of Medic
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Narita H
Nagoya City Sports And Rehabilitation Center
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IIDA Akihiko
Department of Radiology, Nagoya City Rehabilitation Center
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Iida Akihiko
Nagoya City Sports And Rehabilitation Center
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Iida Akihiko
Department Of Oral And Maxillofacial Surgery Faculty Of Dentistry Niigata University
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Ohte Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Miyabe Hiromichi
Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medic
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Yoshida Takayuki
Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medic
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Yoshida Takayuki
Department Of Cardiovascular Medicine Inabe General Hospital
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Narita Hitomi
Department Of Internal Medicine And Pathophysiology Nagoya City University Graduate School Of Medica
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Matsuo Hitoshi
The Department Of Cardiology Gifu Prefectural Hospital
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Ohte Nobuyuki
Department Of Internal Medicine And Pathophysiology Nagoya City University Graduate School Of Medica
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Ohte Nobuyuki
The Third Department Of Internal Medicine Nagoya City University
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Miyabe Hiromichi
National Center For Geriatrics And Gerontology
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Oote Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Narita Hitomi
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Ohte Nobuyuki
The Third Department Of Internal Medicine Nagoya City University Medical School
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Ohte Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Yoshimata T
Department Of Cardiovascular Medicine Inabe General Hospital
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Narita Hitomi
Department Of Internal Medicine And Pathophysiology Nagoya City University Graduate School Of Medica
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Ohte Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Ohte Nobuyuki
Department Of Internal Medicine And Pathophysiology Nagoya City University Graduate School Of Medica
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Hirai Makoto
Department Of Geriatrics Nagoya University Graduated School Of Medicine
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Miyabe Hiromichi
Department Of Cardiology Japanese Red Cross Nagoya First Hospital
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Ohte Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Yoshida Takayuki
Department Of Applied Chemistry Kyushu Institute Of Technology
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Narita Hitomi
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Narita Hitomi
Department Of Internal Medicine And Pathophysiology Nagoya City University Graduate School Of Medica
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Narita Hitomi
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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