Anemia is an Independent Predictor for Elevated Plasma Levels of Natriuretic Peptides in Patients Undergoing Cardiac Catheterization for Coronary Artery Disease
スポンサーリンク
概要
- 論文の詳細を見る
Background It is unknown whether the association of anemia with elevated plasma levels of B-type and atrial natriuretic peptides (BNP and ANP) is mediated by the hemodynamic effects of anemia. Methods and Results The study group comprised 237 consecutive patients (BNP, median [interquartile range], 28.3 [9.5-77.1]pg/ml; ANP, 17.8 [8.5-39.0]pg/ml) undergoing determination of hemoglobin (Hb) and natriuretic peptide levels and cardiac catheterization for evaluation of coronary artery disease (CAD). Hb correlated with BNP (r=-0.36, p<0.001) and ANP (r=-0.35, p<0.001). Patients with anemia (Hb <12g/dl for females; <13g/dl for males, n=63) were more likely to be older with reduced body mass index and renal function, greater severity of CAD and to have higher heart rate, mean pulmonary capillary wedge pressure, and cardiac output. Anemia was a significant predictor for elevated (>third quartile value) natriuretic peptide levels and the predictive value remained significant after adjustment for other predictors, including increased left ventricular end-diastolic pressure and differences in clinical and hemodynamic variables between patients with and without anemia (adjusted odds ratio [95% confidence interval] for elevated BNP and ANP levels, 7.39 [2.76-19.8] and 2.56 [1.08-6.07], respectively). Conclusion Anemia is an independent predictor for elevated natriuretic peptide levels in patients with known or suspected CAD.
- 社団法人日本循環器学会の論文
- 2008-01-20
著者
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Kimura Genjiro
名古屋市立大学 医学研究科心臓･腎高血圧内科学
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Kimura Genjiro
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Kimura G
Department Of Internal Medicine And Pathophysiology Nagoya City University Graduate School Of Medica
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Fukuta Hidekatsu
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medi
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Ohte Nobuyuki
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medi
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Mukai Seiji
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medi
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Mukai Seiji
名古屋市立大学 医学研究科心臓･腎高血圧内科学
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Mukai Seiji
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Kobayashi Kenji
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Kimura G
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Ohte Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Saeki Tomoaki
Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medi
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SATO Takaaki
The Third Department of Internal Medicine
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Ohte Nobuyuki
Department Of Internal Medicine And Pathophysiology Nagoya City University Graduate School Of Medica
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Kobayashi Kenji
Third Department Of Internal Medicine Nagoya City University Medical School
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Saeki Tomoaki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Saeki Tomoaki
The Third Department Of The Internal Medicine Nagoya City University Medical School
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Fukuta Hidekatsu
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Ohte Nobuyuki
The Third Department Of Internal Medicine Nagoya City University
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Oote Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Ohte Nobuyuki
The Third Department Of Internal Medicine Nagoya City University Medical School
-
Ohte Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
-
Mukai Seiji
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Kobayashi Kenji
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
-
Mukai Seiji
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Kimura Genjiro
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Kobayashi Kenji
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Kobayashi Kenji
Departmant Of Zoology Graduate School Of Science Kyoto University
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Ohte Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Ohte Nobuyuki
Department Of Internal Medicine And Pathophysiology Nagoya City University Graduate School Of Medica
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Segawa Tomonori
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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Ohte Nobuyuki
Department Of Cardio-renal Medicine And Hypertension Nagoya City University Graduate School Of Medic
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