Anthraquinones from the Seeds of Cassia tora with Inhibitory Activity on Protein Glycation and Aldose Reductase(Pharmacognosy)
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概要
- 論文の詳細を見る
Nine anthraquinones, aurantio-obtusin (1), chryso-obtusin (2), obtusin (3), chryso-obtusin-2-O-β-D-glucoside (4), physcion (5), emodin (6), chrysophanol (7), obtusifolin (8), and obtusifolin-2-O-β-D-glucoside (9), isolated from an EtOAc-soluble extract of the seeds of Cassia tora, were subjected to in vitro bioassays to evaluate their inhibitory activity against advanced glycation end products (AGEs) formation and rat lens aldose reductase (RLAR). Among the isolates, compounds 6 and 8 exhibited a significant inhibitory activity on AGEs formation with observed IC_<50> values of 118 and 28.9μM, respectively, in an AGEs-bovine serum albumin (BSA) assay by specific fluorescence. Furthermore, compounds 6 and 8 inhibited AGEs-BSA formation more effectively than aminoguanidine, an AGEs inhibitor, by indirect AGEs-ELISA. N^ε-Carboxymethyllysine (CML)-BSA formation was also inhibited by compounds 6 and 8. Whereas compounds 1, 4, and 6 showed a significant inhibitory activity on RLAR with IC_<50> values of 13.6, 8.8, and 15.9μM, respectively.
- 社団法人日本薬学会の論文
- 2007-11-01
著者
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Kim Young
Department of Obstetrics and Gynecology, Women's Cancer Clinic, Yonsei University College of Medicin
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KIM Jin
Departments of Surgery, Seoul National University College of Medicine
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Kim Young
Department Of Electronics Engineering Korea Advance Intitute Of Science & Technology
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Lee Yun
Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins
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JANG Dae
Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine
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LEE Ga
Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine
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LEE Yun
Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine
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KIM Chan-Sik
Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine
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YOO Jeong
Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine
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Kim J‐y
Yeungnam Univ. Taegu Kor
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Lee Ga
Department Of Herbal Pharmaceutical Development Korea Institute Of Oriental Medicine
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Lee Y
Professional Graduate School Of Oriental Medicine And Medicinal Resources Research Institute (merri)
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Kim Jin
Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins
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Kim Young
Department Of Herbal Pharmaceutical Development Korea Institute Of Oriental Medicine
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Jang Dae
Diabetes Res. Center Div. Of Traditional Korean Medicine (tkm) Integrated Res. Korea Inst. Of Orient
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Jang Dae
Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins
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Jang Dae
Department Of Herbal Pharmaceutical Development Korea Institute Of Oriental Medicine
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Yoo Jeong
Department Of Herbal Pharmaceutical Development Korea Institute Of Oriental Medicine
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Kim Jong-bin
Coll. Of Pharmacy Kyung-hee Univ.
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Kim Jong-pyung
Laboratory Of Antioxidants Korea Research Institute Of Bioscience And Biotechnology
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Kim Chan-sik
Department Of Herbal Pharmaceutical Development Korea Institute Of Oriental Medicine
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Kim Joo-hwan
Dep. Of Life Sci. Daejeon Univ.
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Kim Young
Department Of Agricultural Chemistry The University Of Tokyo
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Lee Yun
Department Of Applied Chemistry Saga University
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Kim Jin
Diabetic Complications Res. Center Div. Of Traditional Korean Medicine Integrated Res. Korea Inst. O
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Kim Jin
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Yoo Jeong
Department of Biochemistry and Molecular Biology, College of Pharmacy, Sungkyunkwan University
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