ビンクロゾリンの生殖毒性 : 性成熟期雄ラットに対する暴露の影響(毒性学)
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概要
- 論文の詳細を見る
性成熟期の雄ラットにおける抗真菌剤ビンクロゾリン(VCZ)の生殖に対する毒性影響を調べた.35日齢の雄ラットを6群に分け,陰性コントロールとしてコーンオイル投与群,VCZ100, 200, 400mg/kg投与群,VCZ 200mg/kgとメチルテストステロン100 mg/kg同時投与群,陽性対象としてフルタミド100mg/kg投与群とし,35日齢から44日齢まで毎日経口投与した.最終投与日の翌日に精巣,精巣上体,前立腺等の形態学的,病理組織学的変化と,血中テストステロンレベルの変化を観察し,VCZ処理群で,陽性対象のフルタミド投与群と同等の毒性影響を認めた.また,投与後5週間の動物でも精子数の減少が見られた.性成熟期の雄ラットに対するVCZ投与は生殖毒性を惹起することが明らかになった.
- 社団法人日本獣医学会の論文
- 2004-07-25
著者
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Kim Young
Department Of Electronics Engineering Korea Advance Intitute Of Science & Technology
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Lee B‐j
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee B‐j
Seoul National Univ. Seoul Kor
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Yun Y
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Nam S
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Nam S‐y
Chungbuk National Univ. Cheungju Kor
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Nam Sang-yoon
韓国
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Nam Sang-yoon
東京大学 大学院
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Lee Y
College Of Veterinary Medicine Seoul National University
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Lee Yoon-bok
韓国
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Lee Yb
Central Research Institute Dr. Chung's Food Co. Ltd.
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LEE Yong
College of Pharmacy, Seoul National University
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Kim Yun-bae
Dep. Of Medicine Univ. Of British Columbia Hospital
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Lee Beom
College Of Veterinary Medicine Chungbuk National University
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Kim Young
Department Of Agricultural Chemistry The University Of Tokyo
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HONG Jin
College of Pharmacy and CBITRC, Chungbuk National University
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Kim Y
Department Of Public Health College Of Natural Sciences Keimyung University
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AHN Byeongwoo
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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NAM Sang
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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YUN Young
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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Hong Jin
College Of Pharmacy Chungbuk National University
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Lee Beom
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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YU Wook
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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DO Jae
Gyeongbuk Veterinary Service Laboratory
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Nam Sang-yoon
College Of Veterinary Medicine Konkuk University
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Nam Sang
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Yun Young
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee Y‐b
Central Research Institute Dr. Chung's Food Co. Ltd.
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Hong Jin
College Of Pharmacy And Cbitrc Chungbuk National University
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Yu Wook-joon
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Yu Wook
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Ahn Byeongwoo
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Yun Young
College Of Natural Sciences Department Of Biological Sciences Pusan National University
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Lee B
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee Yong
College Of Pharmacy Chungbuk National University
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Ahn Byeongwoo
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Cho Young
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee Yong
College Of Engineering Yeungnam University
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