Inhibitory Effect of Poncirus trifoliate on Acetylcholinesterase and Attenuating Activity against Trimethyltin-Induced Learning and Memory Impairment
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概要
- 論文の詳細を見る
Various native Korean plants were screened to find an effective acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer’s disease (AD). Among these plants, the ethanol extract of Poncirus trifoliate was selected for isolating the AChE inhibitor because it exhibited the highest inhibitory activity (47.31%). To separate the active compound from Poncirus trifoliate, solvent partition, open column chromatography, thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) were utilized. The putative chemical structure of the AChE inhibitor was identified as methoxsalen by successive analysis with electron ionization mass spectrometry (EI-MS) and 13C/1H-nuclear magnetic resonance (NMR). To confirm the attenuating effect of the Poncirus trifoliate extract against trimethyltin (TMT)-induced neurotoxicity, in vivo behavior tests were carried out. Our findings suggest that the Poncirus trifoliate extract significantly reversed TMT-induced learning and memory impairment. These results demonstrate that the Poncirus trifoliate extract could possess a wide range of beneficial activities for neurodegenerative disorders, notably AD.
- 社団法人 日本農芸化学会の論文
著者
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KIM Hye
Department of Food and Nutrition, Chungnam National University
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Kim Jae
Department of Anatomy, College of Medicine, Pusan National University
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Kim Young
Department Of Electronics Engineering Korea Advance Intitute Of Science & Technology
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KIM Eun
Department of Phpysics, Hanyang University
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Choi Soo
Graduate School Of Life Sciences And Biotechnology Korea Univ.
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Shin Dong-hoon
Department Of Preventive Medicine School Of Medicine & Institute For Medical Genetics Keimyung U
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Bae Heyri
Department of Food and Biotechnology, Korea University
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Kim Mi-Jeong
Brain Korea 21 Project for Medicine, Yonsei University
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CHO Hong
Department of Food and Biotechnology, Korea University
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HWANG Han-Joon
Department of Food and Biotechnology, Korea University
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LIM Seung
Brain Korea 21 Project for Medicine, Yonsei University
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KIM Bok
Han-il Ginseng Industry Company
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