Cytoprotective Effects of KIOM-79 on Streptozotocin Induced Cell Damage by Inhibiting ERK and AP-1(Highlighted paper selected by Editor-in-chief,Biochemistry)

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概要

• 論文の詳細を見る

• The present study investigated the potential cytoprotective properties of a combination of plant extracts (KIOM-79) obtained from Magnolia officinalis, Pueraria lobata, Glycyrrhiza uralensis, and Euphorbia pekinensis, against the oxidative stresses induced by streptozotocin (STZ) in a rat pancreatic β-cells (RINm5F). KIOM-79 was found to scavenge intracellular reactive oxygen species (ROS), thereby preventing DNA damage and lipid peroxidation. The KIOM-79 inhibited apoptosis of the β-cells exposed to STZ via radical scavenging activity and activation of antioxidant enzymes. KIOM-79 inhibited activation of extracellular regulated kinase (ERK) induced by STZ and inhibited DNA binding activity of an activator protein-1 (AP-1), a downstream transcription factor of ERK. Taken together, these findings suggest that KIOM-79 protects against STZ induced cell death in RINm5F cells by inhibiting ROS generation and the ERK pathway.

• 社団法人日本薬学会の論文
• 2007-05-01

著者

• Kim Hee

  Department of Obstetrics and Gynecology, Seoul National University College of Medicine

• KIM Jin

  Departments of Surgery, Seoul National University College of Medicine

• Kim Jin

  韓国

• Son Jong

  Coll. Of Pharmacy Yeungnam Univ.

• Kim So

  Department Of Neuroscience College Of Medicine Ewha Womans University

• Lee Kyoung

  Department Of Biochemistry College Of Medicine And Applied Radiological Science Research Institute C

• Kim So

  Department Of Cardiology College Of Medicine Catholic University Of Daegu

• Kang Kyoung

  School Of Medicine And Applied Radiological Science Research Institute Cheju National University

• Kim Hee

  Department Of Neuroscience College Of Medicine Ewha Womans University

• KANG Kyoung

  Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,

• HYUN Jin

  Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute,

• Hyun Jin

  School Of Medicine And Applied Radiological Science Research Institute Cheju National University

• Kim Jin

  Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar

• Kim Hee

  Department Of Anesthesiology Miller School Of Medicine University Of Miami

• Hyun Jin

  Department Of Biochemistry College Of Medicine Cheju National University

• Kim Hee

  Deparment of Obstetrics and Gynecology, Seoul National University Collge of Medicine

• KANG Kyoung

  College of Medicine, Jeju National University

• Kim So

  Department of Biomedical Engineering, Dongguk University, Seoul 100-715, Korea

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