17-エチニルエストラジオール処理幼若ラットの子宮および膣におけるエストロゲン受容体ER-αとER-βの発現(毒性学)
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概要
- 論文の詳細を見る
17-エチニルエストラジオール(EE)を投与量0,0.03,0.3,1.0,3.0,10.0μg/kg/dayで3日間連続投与した20日齢の幼若ラットの子宮および膣におけるエストロゲン受容体ER-αとER-βの発現を調べた.0.3μg/kg/day以上のEE投与で子宮と膣の重量は有意に増加し,子宮に水腫が見られた.3.0μg/kg/day以上の高投与量では子宮長の増加と,肥大,ER-αとER-βの子宮管腔および腺上皮における発現の減少,腫上皮における角質化とER-αとER-βの発現の低下が見られた.これらの結果から,幼君ラットに対するEE処理は子宮と膣のER-αとER-βの発現を低下させ,これが,子宮上皮の肥大や子宮長の増加,膣の角質化に関連していると考えられた.
- 2003-12-25
著者
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CHOI Mincheol
College of Veterinary Medicine, Seoul National University
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Lee B‐j
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee B‐j
Seoul National Univ. Seoul Kor
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Yun Y
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Kwon D
Seoul National Univ. Seoul Kor
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Nam S
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Nam Sang-yoon
韓国
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Nam Sang-yoon
東京大学 大学院
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Lee Y
College Of Veterinary Medicine Seoul National University
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Lee Yoon-bok
韓国
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Lee Yb
Central Research Institute Dr. Chung's Food Co. Ltd.
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LEE Yong
College of Pharmacy, Seoul National University
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Lee Beom
College Of Veterinary Medicine Chungbuk National University
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Choi M.
韓国
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Jang Dong
National Institute Of Toxicology Research Korea Food And Drug Administration
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KIM Hyung
National Institute of Information and Communications Technology
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KANG Jin
National Institute of Toxicology Research, Korea Food and Drug Administration
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AHN Byeongwoo
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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KIM Dae
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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NAM Sang
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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YUN Young
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ
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NAM Ki
National Institute of Toxicology Research, Korea Food and Drug Administration
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CHOI Mina
National Institute of Toxicology Research, Korea Food and Drug Administration
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YANG Ki-Hwa
National Institute of Toxicology Research, Korea Food and Drug Administration
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Lee Beom
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Nam Ki
National Institute Of Toxicology Research Korea Food And Drug Administration
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Nam Sang-yoon
College Of Veterinary Medicine Konkuk University
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Nam Sang
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Yun Young
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee Y‐b
Central Research Institute Dr. Chung's Food Co. Ltd.
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Kang Jin
National Institute Of Toxicology Research Korea Food And Drug Administration
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Yang Ki-hwa
National Institute Of Toxicological Research
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Yang Ki-hwa
National Institute Of Toxicology Research Korea Food And Drug Administration
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Choi Mina
National Institute Of Toxicology Research Korea Food And Drug Administration
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Kim Dae
College Of Pharmacy Seoul National University
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Ahn Byeongwoo
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Yun Young
College Of Natural Sciences Department Of Biological Sciences Pusan National University
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Kim Dae
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee B
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Lee Yong
College Of Pharmacy Chungbuk National University
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Ahn Byeongwoo
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive
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Kim Dae
College Of Pharmacy Chung-ang University
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Kim Hyung
National Institute Of Toxicology Research Korea Food And Drug Administration
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Kim Dae
College Of Life Sciences And Biotechnology Korea University
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Lee Yong
College Of Engineering Yeungnam University
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KIM Hyung
National Fusion Research Institute
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