Evaluation of Physicochemical Properties, Skin Permeation and Accumulation Profiles of Ketorolac Fatty Ester Prodrugs(Biopharmacy)

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概要

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• The purpose of this study was to evaluate the physicochemical properties, skin permeation and accumulation profiles of model lipophilic ketorolac fatty ester (esters) prodrugs. Ketorolac linoleate (C18: 2), oleate (C18: 1) and stearate (C18: 0) were evaluated for their solubility, capacity factor, enzymatic hydrolysis, chemical stability, and skin permeation and accumulation profiles using the combination of common permeation enhancing techniques such as the use of supersaturated solution of permeants in the enhancer vehicle, lipophilic receptor solution, enhancer pretreatment of skins, removal of stratum corneum and delipidization of skins etc. Esters were highly lipophilic, chemically stable for the duration of observation, enzymatically unstable in hairless mouse skin/liver homogenates and plasma, and impermeable into the receptor solution. Absence of skin permeation, relative enzymatic stability during permeation and chemical stability of these esters could delineate preliminary possibilities for designing safer topical agents without systemic absorption.

• 公益社団法人日本薬学会の論文
• 2007-11-01

著者

• KIM Jung

  Department of Occupational Medicine, College of Medicine, Dong-A University

• LEE Jae

  Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine

• Bhandari Krishna

  College Of Pharmacy Yeungnam University

• Bhandari Krishna

  韓国

• Woo Jong

  College of Pharmacy, Yeungnam University

• Yong Chul

  College of Pharmacy, Yeungnam University

• Choi Han-Gon

  College of Pharmacy, Yeungnam University

• Kim Jung

  College Of Pharmacy Yeungnam University

• Kim Jung

  韓国

• Yoon Sung

  Department of Cardiology, School of Medicine, Keio University

• Yong Chul

  Coll. Of Pharmacy Yeungnam Univ.

• Yong Chul

  韓国

• Yong Chul

  College Of Pharmacy Yeungnam University

• Choi Han-gon

  Coll. Of Pharmacy Yeungnam Univ.

• Choi Han-gon

  韓国

• Choi Han

  College Of Pharmacy Yeungnam University

• Woo Jong

  Coll. Of Pharmacy Yeungnam Univ.

• Kim Jong

  Coll. Of Pharmacy Yeungnam Univ.

• Woo Jong

  韓国

• Choi Han

  Coll. Of Pharmacy Yeungnam Univ.

• Choi H‐g

  College Of Pharmacy Yeungnam University

• Kim J‐s

  College Of Pharmacy Yeungnam University

• Jang Ki

  College Of Pharmacy Yeungnam University

• KIM Dae

  College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ

• Kim Jung

  Department Of Applied Chemistry School Of Engineering The University Of Tokyo

• KIM Jung-Ae

  College of Pharmacy, Yeungnam University

• YOO Bong

  College of Pharmacy, Yeungnam University

• NEWA Madhuri

  College of Pharmacy, Yeungnam University

• CHOI Hang

  College of Pharmacy, Yeungnam University

• Yoon Sung

  Department Of Biotechnology Dongseo University

• Lee Jae

  Division Of Cardiology Asan Medical Center University Of Ulsan College Of Medicine

• Kim Jung-ae

  College Of Pharmacy Yeungnam University

• Yoo Bong

  College Of Pharmacy Yeungnam University

• Yoo Bong-kyu

  College Of Pharmacy Yeungnam University

• Kim Dae

  College Of Pharmacy Seoul National University

• Newa Madhuri

  College Of Pharmacy Yeungnam University

• Kim Jung

  Department Of Biotechnology Dongseo University

• Kim Jung-ae

  Coll. Of Pharmacy Yeungnam Univ.

• Lee Jae

  Division Of Pharmaceutical Sciences Chung-ang University

• Kim Dae

  College Of Pharmacy Chung-ang University

• Yoo Bong

  Coll. Of Pharmacy Yeungnam Univ.

• Kim Dae

  College Of Life Sciences And Biotechnology Korea University

• Newa Madhuri

  韓国

• Kim Jung

  Department Of Applied Bioscience Cha University

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