Poloxamer 188 and Propylene Glycol-Based Rectal Suppository Enhances Anticancer Effect of 5-Fluorouracil in Mice(Biopharmacy)
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概要
- 論文の詳細を見る
The tumoricidal and apoptosis-inducing activities of 5-fluorouracil (5-FU) have been demonstrated in experimental and clinical investigations. Clinically, the 5-FU suppository form has been widely adopted for its advantages of less systemic toxicity, higher local tissue concentrations, and reduced first-pass effect. In this study, we investigated the feasibility of rectal administration of 5-FU suppository based on poloxamer 188 (P188) and propylene glycol (PG) and its anticancer effect on the murine experimental cancer models. The rectal suppository was made with 70% P188 and 30% PG, which was a solid phase at room temperature and instantly melted at physiological temperature. The treatment with the 5-FU suppository was more effective than the oral route in decreasing the volume of rectal cancer in mice. In addition, the survival rate of the mice with rectal cancer was higher in the group treated with the 5-FU suppository than in the group treated with 5-FU orally. Furthermore, in mice skin cancers induced by inoculation of murine CT-26 colon carcinoma cells, the anticancer effect of 5-FU was significantly enhanced by the rectal administration of the suppository than by oral treatment. Taken together, the results suggest that a poloxamer gel system with 5-FU/P188/PG is an effective rectal dosage form for the treatment of both rectal and non-rectal cancers.
- 公益社団法人日本薬学会の論文
- 2006-05-01
著者
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Choi Han-Gon
College of Pharmacy, Yeungnam University
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Kim Jung
College Of Pharmacy Yeungnam University
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Choi Han-gon
Coll. Of Pharmacy Yeungnam Univ.
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Choi Han-gon
韓国
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Choi Han
College Of Pharmacy Yeungnam University
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Choi Han-gon
College Of Pharmacy Yeungnam University
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Kim Jong
Coll. Of Pharmacy Yeungnam Univ.
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Choi Han
Coll. Of Pharmacy Yeungnam Univ.
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Choi H‐g
College Of Pharmacy Yeungnam University
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Park Byung
College Of Pharmacy Yeungnam University
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Oh Yu-kyoung
School Of Life Sciences And Biotechnology Korea University
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KIM Jung-Ae
College of Pharmacy, Yeungnam University
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Lee Yoon-seok
College Of Pharmacy Yeungnam University
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PAEK Seung-Hwan
College of Pharmacy, Yeungnam University
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XUAN Jing-Ji
College of Pharmacy, Yeungnam University
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JEONG Tae-Cheon
College of Pharmacy, Yeungnam University
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JIN Chun
College of Pharmacy, Yeungnam University
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Kim Jung-ae
College Of Pharmacy Yeungnam University
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Paek Seung-hwan
College Of Pharmacy Yeungnam University
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Xuan Jing-ji
College Of Pharmacy Yeungnam University
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Jin Chun
College Of Pharmacy And Research Center For Bioresource And Health Chungbuk National University
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Kim Jung
Department Of Biotechnology Dongseo University
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Paek Seung
College Of Pharmacy Yeungnam University
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Kim Jung-ae
Coll. Of Pharmacy Yeungnam Univ.
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Jeong Tae-cheon
College Of Pharmacy Yeungnam University
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Jin Chun
College Of Pharmacy Yeungnam University
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