Mycelial Extract of Cordyceps ophioglossoides Prevents Neuronal Cell Death and Ameliorates β-Amyloid Peptide-Induced Memory Deficits in Rats(Pharmacology)
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概要
- 論文の詳細を見る
Ameliorating effects of methanol extracts of Basidiomycetes against in vitro and in vivo model of Alzheimer's disease were investigated. The extracts of Cordyceps ophioglossoides and Hypocrea citrina var. citrina prevented the β-amyloid_<(25-35)> (Aβ_<(25-35)>)-induced cell death in SK-N-SH neuronal cells. However, in rat model of Alzheimer's disease, 30-d intraperitoneal administration with only the extract of Cordyceps ophioglossoides significantly prevented spatial memory loss by intracranial injection of Aβ_<(25-35)>, which was assessed in water maze task. Interestingly, the scavenging activity of the reactive oxygen species (ROS) generated in Aβ_<(25-35)>-treated cells was also found in the extract of Cordyceps ophioglossoides, but not in the extract ofHypocrea citrina var. citrina. These results suggest that the extract of Cordyceps ophioglossoides may protect the Aβ-induced neuronal cell death and memory loss through free radical scavenging activity. These results further suggest that Cordyceps ophioglossoides mycelium may be valuable for the protection from Alzheimer's dementia.
- 公益社団法人日本薬学会の論文
- 2004-07-01
著者
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Park Byung-chul
Department Of Orthopedic Surgery Kyungpook National University Hospital
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JIN Da-Qing
College of Pharmacy, Yeungnam University
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KIM Jung-Ae
College of Pharmacy, Yeungnam University
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Kim Jung-ae
College Of Pharmacy Yeungnam University
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Yang Jae-ha
Department Of Pharmacology Daegu Haany University
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Jin Da-qing
College Of Pharmacy Yeungnam University
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Lee Yong-soo
College Of Pharmacy Duksung Women's University
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Lee Jae-seong
College Of Natural Resources Yeungnam University
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Park Byung-chul
College Of Pharmacy Yeungnam University
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CHOI Hee-Don
Korea Food Research Institute
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Choi Hee-Don
Korea Food Research Institue
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