Anti-glycation Effect of Gold Nanoparticles on Collagen

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概要

• 論文の詳細を見る

• Gold nanoparticles (GNPs) have been reported to exhibit a variety of biological effects including anti-inflammatory and anti-oxidant activities. The extent of an in vitro glycation reaction mixture of collagen and glycolaldehyde was assayed to investigate the inhibition of glycolaldehye-derived advanced glycation end products (glycol-AGEs) formation with GNPs in collagen, which is a major protein component of the human dermis. GNP-treated collagen showed significantly less glycation (56.3±4.2%) than an untreated glycation control. Moreover, GNP-treated glycation in a collagen lattice model significantly decreased the AGEs distribution in the model system. Taken together, these results suggest that GNPs have the potential for use in the prevention of glycation-induced skin aging.

• 公益社団法人　日本薬学会の論文

著者

• CHOI Hee-Don

  Korea Food Research Institute

• Koo Yun-chang

  Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University

• Lee Kwang-Won

  Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University

• Kim Ji-hoon

  Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University

• Hong Chung-Oui

  Department of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University

• Choi Hee-Don

  Korea Food Research Institue

関連論文

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• Protective Effect of (-)-Epigallocatechin Gallate against Advanced Glycation Endproducts-Induced Injury in Neuronal Cells(Analytical Biochemistry)
• Anti-glycation Effect of Gold Nanoparticles on Collagen

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