Inhibitory Effects of Asiatic Acid on 7,12-Dimethylbenz[a]anthracene and 12-O-Tetradecanoylphorbol 13-Acetate-Induced Tumor Promotion in Mice(Pharmacology)
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概要
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Asiatic acid, a pentacyclic triterpene, has been reported to induce apoptosis of various human cancer cells. In the present study, we assessed the anti-tumor promoting effect of asiatic acid against 12-O-tetradecanoylphorbol 13-acetate (TPA)-mediated skin tumorigenesis in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated ICR mice. Topical application of asiatic acid prior to each application of TPA resulted in a significant reduction in skin tumor formation. We also found that pre-application of asiatic acid alleviated TPA-induced [^3H]thymidine incorporation, which is a conventional marker for skin tumor promotion. In addition, asiatic acid inhibited the TPA-induced generation of nitric oxide (NO) and expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), which are known to play important roles in tumor growth, especially in the promotion stage. In addition, topical application of aminoguanidine (AG), a selective iNOS inhibitor, and N^G-nitro-L-arginine-methyl ester (NAME), another iNOS inhibitor, 30 min prior to TPA treatment significantly inhibited the TPA-induced COX-2 expression. These results suggest that asiatic acid may exert anti-tumorigenesis through inhibitory actions in NO and COX-2 signals.
- 公益社団法人日本薬学会の論文
- 2007-01-01
著者
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Yong Chul
College of Pharmacy, Yeungnam University
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Choi Han-Gon
College of Pharmacy, Yeungnam University
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Kim Jung
College Of Pharmacy Yeungnam University
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Kim Jung
韓国
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Yong Chul
Coll. Of Pharmacy Yeungnam Univ.
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Yong Chul
韓国
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Yong Chul
College Of Pharmacy Yeungnam University
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Choi Han-gon
Coll. Of Pharmacy Yeungnam Univ.
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Choi Han-gon
韓国
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Choi Han
College Of Pharmacy Yeungnam University
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Kim Jong
Coll. Of Pharmacy Yeungnam Univ.
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Choi Han
Coll. Of Pharmacy Yeungnam Univ.
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LEE Eung-Seok
College of Pharmacy, Yeungnam University
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Choi H‐g
College Of Pharmacy Yeungnam University
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Kim J‐s
College Of Pharmacy Yeungnam University
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Park Byung
College Of Pharmacy Yeungnam University
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KIM Jung-Ae
College of Pharmacy, Yeungnam University
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Lee Yoon-seok
College Of Pharmacy Yeungnam University
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PAEK Seung-Hwan
College of Pharmacy, Yeungnam University
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KIM Seung-Joo
College of Pharmacy, Yeungnam University
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Kim Jung-ae
College Of Pharmacy Yeungnam University
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Paek Seung-hwan
College Of Pharmacy Yeungnam University
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Lee Eung-seok
College Of Pharmacy Yeungnam University
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Kim Seung-joo
College Of Pharmacy Yeungnam University
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Kim Jung
Department Of Biotechnology Dongseo University
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Paek Seung
College Of Pharmacy Yeungnam University
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Kim Jung-ae
Coll. Of Pharmacy Yeungnam Univ.
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Lee E‐s
College Of Pharmacy Yeungnam University
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