Enhancement of Solubility, Dissolution and Bioavailability of Ibuprofen in Solid Dispersion Systems
スポンサーリンク
概要
- 論文の詳細を見る
To improve its solubility, dissolution, and bioavailability; Ibuprofen-polyethylene glycol 8000 (PEG 8000) solid dispersions (SDs) with different drug loadings were prepared, characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC), and evaluated for solubility, in-vitro release, and oral bioavailability of ibuprofen in rats. Loss of individual surface properties during melting and solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C_<max>, and a significant decrease in T_<max> over pure ibuprofen. Preliminary results of this study suggested that the preparation of ibuprofen SDs using PEG 8000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution and bioavailability of ibuprofen.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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Bhandari Krishna
College Of Pharmacy Yeungnam University
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Bhandari Krishna
韓国
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Kim Jong
College of Pharmacy, Yeungnam University
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Woo Jong
College of Pharmacy, Yeungnam University
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Yong Chul
College of Pharmacy, Yeungnam University
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Choi Han-Gon
College of Pharmacy, Yeungnam University
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Kim Jung
College Of Pharmacy Yeungnam University
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Kim Jung
韓国
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Yong Chul
Coll. Of Pharmacy Yeungnam Univ.
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Yong Chul
韓国
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Yong Chul
College Of Pharmacy Yeungnam University
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Choi Han-gon
Coll. Of Pharmacy Yeungnam Univ.
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Choi Han-gon
韓国
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Choi Han
College Of Pharmacy Yeungnam University
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Woo Jong
Coll. Of Pharmacy Yeungnam Univ.
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Kim Jong
Coll. Of Pharmacy Yeungnam Univ.
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Woo Jong
韓国
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Choi Han
Coll. Of Pharmacy Yeungnam Univ.
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Choi H‐g
College Of Pharmacy Yeungnam University
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Kim J‐s
College Of Pharmacy Yeungnam University
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YOO Bong
College of Pharmacy, Yeungnam University
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NEWA Madhuri
College of Pharmacy, Yeungnam University
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IM Jong
College of Pharmacy, Yeungnam University
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Im Jong
College Of Pharmacy Yeungnam University
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Kim Jung-ae
College Of Pharmacy Yeungnam University
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Yoo Bong
College Of Pharmacy Yeungnam University
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Yoo Bong-kyu
College Of Pharmacy Yeungnam University
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Newa Madhuri
College Of Pharmacy Yeungnam University
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Kim Jung
Department Of Biotechnology Dongseo University
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Kim Jung-ae
Coll. Of Pharmacy Yeungnam Univ.
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Kim Jong
College Of Oriental Medicine Daegu Haany University
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Kim Jong
College Of Medicine Yeungnam University
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Yoo Bong
Coll. Of Pharmacy Yeungnam Univ.
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Newa Madhuri
韓国
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