Expression of Mitochondrial Capsule Selenoprotein mRNA Increases with Aging, but Decreases by Selenium Deficiency in the Mouse Testis
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概要
- 論文の詳細を見る
Mitochondrial capsule selenoprotein (MCS) has been known as a structural protein of the mitochondrial sheath in spermatozoa. In this study, to investigate whether or not the expression of MCS mRNA in testes is affected by aging or selenium (Se) deficiency, the cDNA clone of MCS was isolated from the testes of 8-week-old ICR mice by reverse transcription-polymerase chain reaction. The nucleic acid sequence analysis confirmed that the cloned cDNA is an open reading frame of the MCS and contains 3 in-phase TGA codons that recognize specifically the selenocysteine in selenoprotein. According to Northern blot analysis, the MCS mRNA in testes greatly increased at 8 weeks old and then began to increase with aging. As compared with that of 8-week-old mice, the signal increased about 2.4-fold in the testes of 80-week-old mice. On the other hand, we generated Se-deficient and Se-sufficient mice by feeding weanling male mice (3 weeks old) with either a Se-deficient or a Se-sufficient diet for 11 weeks. MCS mRNA decreased about 21-fold in the testes of Se-deficient animals as compared with that of Se-sufficient animals. The present study provides a novel evidence that MCS mRNA level in testes increases with aging, but remarkably decreases due to Se deficiency.
- 日本繁殖生物学会の論文
著者
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HAYASHI Yoshihiro
Department of Pathology, Kochi Medical School, Kochi University
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Nam S
College Of Veterinary Medicine And Research Institute Of Veterinary Medicine
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Youn Hwa-young
Department Of Veterinary Internal Medicine College Of Veterinary Medicine Seoul National University:
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KUROHMARU Masamichi
Department of Veterinary Anatomy, Graduate School of Agricultural and Life Sciences, The University
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NAM Sang-Yoon
Department of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National U
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OGAWA Kenji
Laboratory Animal Research Center, The Institute of Phsical and Chemical Research (RIKEN)
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