Localization of the Cytochrome P450 Side-Chain Cleavage Enzyme in the Inactive Testis of the Naked Mole-Rat
スポンサーリンク
概要
- 論文の詳細を見る
Spermatogenesis was histologically examined in non-breeding male of the naked mole rat (Heterocephalus glaber) using a light microscopy. Spermatogonia, spermatocytes and spermatids were confirmed in the seminiferous tubules. However, the spermatogenesis was disordered, and many spermatocytes and spermatids were sloughing. Sperms could not be seen in the lumen of the tubules. The characteristic accumulation of interstitial cells was the most noteworthy. In the immunohistochemistry for cytochrome P450 side-chain cleavage enzyme, immunoreactions were not entirely distributed in each interstitial cell, although positive reactions were scattered in the interstitial cell-mass. The findings indicate that few interstitial cells act as a testosterone-synthesizing apparatus in the characteristic structure with accumulated cell-mass. From the immunohistochemical data we suggest the possibility that spermatogonia and Sertoli cells may secrete 17β-estradiol. We also suggest that 17β-estradiol from spermatogonia and Sertoli cells may inhibit the interstitial cells from synthesizing and secreting testosterone and may suppress the later stages of the spermatogenesis to induce apoptosis of germ cells. The TUNEL methods demonstrated that cell death occurred in some spermatocytes in non-breeding males.
- 社団法人日本動物学会の論文
- 2002-06-25
著者
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HAYASHI Yoshihiro
Department of Pathology, Kochi Medical School, Kochi University
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Kimura Junpei
Department of Veterinary Anatomy, College of Veterinary Medicine and Research Institute for Veterina
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木村 順平
第7回日本野生動物医学会大会事務局
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岡の谷 一夫
千葉大学文学部
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Okanoya K
National Agriculture Res. Center Tsukuba Jpn
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Okanoya Kazuo
Faculty Of Letters Chiba University
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Okanoya Kazuo
Department Of Cognitive And Information Sciences Faculty Of Letters Chiba University:presto Japan Sc
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Okanoya Kazuo
Graduate School Of Science And Technology Chiba University:faculty Of Letters Chiba University:prest
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佐々木 基樹
帯広畜産大学獣医解剖学分野:岐阜大学大学院連合獣医学研究科
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Sasaki Motoki
Department Of Basic Veterinary Sciences Obihiro University Of Agriculture And Veterinary Medicine
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Kimura Junpei
Department Of Veterinary Anatomy College Of Bioresource Sciences Nihon University
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Sasaki M
Obihiro Univ. Agriculture And Veterinary Medicine Obihiro Jpn
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Endo Hideki
Department of Zoology, National Science Museum
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Suzuki Masatsugu
Graduate School Of Veterinary Medicine Hokkaido University
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Suzuki Masatsugu
Laboratory Of Wildlife Biology Department Of Environmental Veterinary Science Graduate School Of Vet
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Sasaki M
Laboratory Of Veterinary Anatomy Department Of Basic Veterinary Medicine Obihiro University Of Agric
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Endo Hideki
Univ. Tokyo Tokyo Jpn
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Endo H
The University Museum The University Of Tokyo
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Endo Hideki
Department Of Zoology National Science Museum
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ENDO Hideki
The University Museum, The University of Tokyo
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Endo Hideki
The University Museum The University Of Tokyo
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Hayashi Yoshihiro
Department Of Pathology Kochi Medical School Kochi University
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Hayashi Y
Department Of Veterinary Anatomy Graduate School Of Agricultural And Life Sciences The University Of
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木村 順平
日本大学生物資源科学部獣医解剖学教室
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Okanoya Kazuo
Gruduate School Of Sci. And Technol. Chiba Univ.
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Park Thomas
Department of Biological Science, University of Illinois at Chicago
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Tanemura Kentaro
Laboratory of Alzheimer's Disease, Brain Science Institute, RIKEN
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Park Thomas
Department Of Biological Science University Of Illinois At Chicago
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Sasaki Motoki
Department Of Basic Veterinary Medicine Obihiro University Of Agriculture And Veterinary Medicine
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Sasaki Motoki
Laboratory Of Veterinary Anatomy Department Of Basic Veterinary Medicine Obihiro University Of Agric
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Endo Hideki
Department Of Veterinary Public Health Faculty Of Veterinary Medicine Hokkaido University
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Endo Hideki
Department Of Veterinary Anatomy Obihiro University Of Agriculture And Veterinary Medicine
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Hayashi Y
Department Of Global Agricultural Sciences Graduate School Of Agriculture And Agricultural Life Scie
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Hayashi Yoshihiro
Department Of Micro System Engineering School Of Engineering Nagoya University
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Tanemura Kentaro
Laboratory Of Alzheimer's Disease Brain Science Institute Riken
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Sawata M
Faculty Of Agriculture Tamagawa University
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Kimura Junpei
Department Of Veterinary Anatomy And Cell Biology College Of Veterinary Medicine Seoul National Univ
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Hayashi Yoshihiro
Department Of Gastroenterology Faculty Of Medicine Fukuoka University
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KIMURA Junpei
Department of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul 151–742, Korea
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Hayashi Yoshihiro
Department of Applied Chemistry, Institute of Colloid and Interface Science, Science University of Tokyo
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