Modulating Effects of Korean Ginseng Saponins on Ovarian Function in Immature Rats(Pharmacognosy)

概要

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The modulating effects of Korean ginseng saponins on ovarian functions were investigated in immature rats superovulated with pregnant mare serum gonadotropin (PMSG). A single dose of 1 mg (0.1 ml/head) of Korean ginseng total saponin (GTS), Korean ginseng protopanaxatriol saponin (GPT), Korean ginseng protopanaxadiol saponin (GPD), or ginsenoside-Rb_1 (Gin-Rb_1) was intravenously injected via jugular vein catheter three times at 1 h (early follicular phase), 25 h (middle follicular phase), and 50 h (late follicular phase) after 30 IU PMSG administration. GPD and Gin-Rb1 significantly suppressed excessive ovulatory response caused by PMSG (p<O.05). All Korean ginseng saponins significantly improved oocyte quality by decreasing the proportion of abnormal oocytes (p<O.O5). Gin-Rb_1 significantly decreased preovulatory serum levels of androgens and 17β-estradiol, while GPD increased preovulatory serum progesterone level (p<O.05). GPD significantly the increased postovulatory serum progesterone level (p<O.O5). These results provide strong evidence that Korean ginseng saponins have a curative effect on ovarian dysfunction caused by excessive stimulation with PMSG.
社団法人日本薬学会の論文
2003-11-01