Suppression of Cholangiocarcinoma Development by Aminoguanidine in the Liver Fluke-infested Hamster
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概要
- 論文の詳細を見る
Clonorchis sinensis (CS) infection combined with hepatocarcinogen treatment results in marked cholangiocarcinoma (CC) formation in hamsters. Hamsters were kept for 16 weeks with or without 1% aminoguanidine (AG) exposure through drinking water, and were treated with dimethylnitrosamine for 4 weeks, 2 days after being infected orally with 15 metacercariae of CS. Interestingly, of the 11 hamsters not treated with AG, 9 had malignant tumors, 1 had a benign tumor, and 1 was normal; however, of the 10 hamsters treated with AG, 5 had benign tumors, 4 had malignant tumors, and 1 was normal. Based on this result, AG has an inhibitory effect on the progression of CC. Further mechanistic study into the result of this morphological study is warranted.
- 日本毒性病理学会の論文
- 2005-03-30
著者
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HAN Jeong-Hee
Department of Veterinary Medicine, Kangwon National University
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Yoon Byung-il
Department Of Veterinary Medicine Kangwon National University
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Kim Dae-yong
Department Of Veterinary Pathology College Of Veterinary Medicine Seoul National University And Scho
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Kim Dae-yong
Department Of Veterinary Pathology College Of Veterinary Medicine And School Of Agricultural Biotech
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Kim Dae-yong
Department Of Pathology College Of Veterinary Medicine Seoul National University
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Jang Dong-deuk
National Institute Of Toxicological Research
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YANG Ki-Hwa
National Institute of Toxicology Research, Korea Food and Drug Administration
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Park Mi-sun
Department Of Veterinary Pathology College Of Veterinary Medicine And School Of Agricultural Biotech
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Yang Ki-hwa
National Institute Of Toxicological Research
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NAM Ki-Taek
National Institute of Toxicological Research
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Han Jeong-hee
Department Of Velterinary Medicine Kangwon National University
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