Canonical Wnt Signaling Pathway Plays an Essential Role in N-Methyl-N-Nitrosurea Induced Gastric Tumorigenesis of Mice
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概要
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Deregulated Wnt signaling pathway is implicated in many hereditary diseases and tumorigenesis including colorectal cancer, hepatocellular carcinoma and gastric cancer. In this study, to assess the relationship between chemically induced gastric tumor and canonical Wnt signaling pathway in genetically intact mice, histopathological and quantitative mRNA analyses were performed in C57BL/6J mice given drinking water containing N-methyl-N-nitrosurea (MNU). 60.5% of gastric adenoma and 27.9% of adenocarcinoma were observed 48 weeks after first administration. Also, in immunohistochemical analysis, aberrant expressions of phospho-GSK-3β, β-catenin, cyclin D1, c-Myc, osteopontin and COX-2 were found. In double immunofluorescent-antibody stains, β-catenin accumulation was colocalized with other proteins. mRNA levels of cyclin D1, c-myc and COX-2 were relatively higher in adenocarcinoma. Altogether, canonical Wnt pathway was highly involved in MNU induced gastric neoplasia of C57BL/6J mice, and it could be a considerably suitable system for the study to examine the linkage between gastric tumorigenesis and the canonical Wnt pathway.
著者
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JEONG Eui-Suk
Department of Biological Sciences, College of Sciences, Konkuk University
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Kim Dae-yong
Department Of Pathology College Of Veterinary Medicine Seoul National University
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CHOI Yang-Kyu
Department of Electrical Engineering and Computer Science, University of California
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Seo Jin-hee
Department Of Laboratory Animal Medicine College Of Veterinary Medicine Konkuk University
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Heo Seung-ho
Department Of Laboratory Animal Medicine College Of Veterinary Medicine Konkuk University
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Lee Kyoung-sun
Department Of Laboratory Animal Medicine College Of Veterinary Medicine Konkuk University
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KWON Hyo-Jung
Biomedical Mouse Resource Center, Korea Research Institute of Bioscience and Biotechnology
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JEONG Dong-Gu
Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University
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WON Young-Suk
Biomedical Mouse Resource Center, Korea Research Institute of Bioscience and Biotechnology
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KIM Hyoung-Chin
Biomedical Mouse Resource Center, Korea Research Institute of Bioscience and Biotechnology
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CHOI Yang-Kyu
Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143–701, Republic of Korea
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KIM Hyoung-Chin
Biomedical Mouse Resource Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363–883, Republic of Korea
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LEE Kyoung-Sun
Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143–701, Republic of Korea
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KIM Dae-Yong
Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul 151–742, Republic of Korea
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HEO Seung-Ho
Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143–701, Republic of Korea
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