Antiplatelet Effect of 2-Chloro-3-(4-acetophenyl)-amino-1, 4-naphthoquinone(NQ301) : A Possible Mechanism through Inhibition of Intracellular Ca^<2+>Mobilization

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of 2-chloro-3-(4-acetophenyl)-amino-1, 4-naphthoquinone(NQ301), an antithrombotic agent, on aggregation, binding of fibrinogen to glycoprotein(GP)IIb/IIIa complex and intracellular signals were investigated using human platelets. NQ301 significantly inhibited the collagen-, thrombin-, arachidonic acid-, thapsigargin- and calcium ionophore A23187-induced aggregation of washed human platelets with IC_50 values of 13.0±0.1, 11.2±0.5, 21.0±0.9, 3.8±0.1 and 46.2±0.8μ_M, respectively. NQ301 also significantly inhibited FITC-conjugated fibrinogen binding to human platelet surface GPIIb/IIIa complex, but failed to inhibit the fibrinogen binding to purified GPIIb/IIIa complex. These data demonstrate that NQ301 inhibits platelet aggregation by suppresion of the intracellular pathway, rather than by direct inhibition of fibrinogen-GPIIb/IIIa complex binding. NQ301 significantly inhibited the increase of cytosolic Ca^<2+> concentration and ATP secretion, and also signficantly increased platelet cAMP levels in the activated platelets. These results suggest that the antiplatelet activity of NQ301 may be mediated by inhibition of cytosolic Ca^<2+> mobilization, enhancement of cAMP production and inhibition of ATP secretion in activated platelets.

• 公益社団法人日本薬学会の論文
• 2001-06-01

著者

• Yun Yeo-Pyo

  College of Pharmacy, Chungbuk National University

• Zhang Yong-he

  College Of Pharmacy Chungbuk National University

• Yun Yeo-pyo

  Coll. Of Pharmacy Chungbuk National Univ.

• Yun Yeo-pyo

  College Of Pharmacy Research Center For Bioresource And Health Chungbuk National University

• Yun Y‐p

  Chungbuk National Univ. Cheongju Kor

• Yun Yeo-pyo

  College Of Pharmacy Chungbuk National University

• Chung Kwang-hoe

  Cardiovascular Research Institute Yonsei University College Medicine

• Ko Myong-hwa

  College Of Pharmacy Chungbuk National University

• Ryu Chung-kyu

  College Of Phamacy Ewha Womans University

• LEE Myung-Koo

  College of Pharmacy, Chungbuk National University

• Lee Myung-koo

  College Of Pharmacy Chungbuk National University

• Yun Yeo-pyo

  College Of Pharmacy Cbitrc College Of Pharmacy And Medical Research Center Chungbuk National Univers

• Yun Yeo-Pyo

  College of Pharmacy and Medical Research Center, Chungbuk National University

関連論文

• Potent inhibition of platelet-derived growth factor-stimulated rat aortic vascular smooth muscle cell cycle and proliferation by (2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-1-one, a newly synthesized benzylideneacetophenone derivative
• Potent Inhibition of Platelet-Derived Growth Factor-Stimulated Rat Aortic Vascular Smooth Muscle Cell Cycle and Proliferation by (2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-1-one, a Newly Synthesized Benzylideneacetophenone Derivative
• Corynoxeine Isolated from the Hook of Uncaria rhynchophylla Inhibits Rat Aortic Vascular Smooth Muscle Cell Proliferation through the Blocking of Extracellular Signal Regulated Kinase 1/2 Phosphorylation(Pharmacology)
• Effects of [5-(2-Methoxy-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32560), a Novel Sodium/Hydrogen Exchanger-1 Inhibitor, on Myocardial Infarct Size and Ventricular Arrhythmias in a Rat Model of Ischemia/Reperfusion Heart Injury
• Inhibitory Effects of BST406, a Newly Synthesized Benzylideneacetophenone Derivative, on Abnormal Vascular Smooth Muscle Cell Proliferation
• Genistein Inhibits Rat Aortic Smooth Muscle Cell Proliferation Through the Induction of p27^
• Antiplatelet Effect of NQ12 : a Possible Mechanism Through the Arachidonic Acid Cascade
• Cudratricusxanthone A Isolated from the Root Bark of Cudrania tricuspidata Inhibits the Proliferation of Vascular Smooth Muscle Cells through the Suppression of PDGF-Receptor Beta Tyrosine Kinase(Pharmacology)
• Inhibitory Effects of Anti-Inflammatory Drugs on Interleukin-6 Bioactivity
• A Novel Metalloprotease from Gloydius halys Venom Induces Endothelial Cell Apoptosis through Its Protease and Disintegrin-Like Domains
• Sauchinone Attenuates Oxidative Stress-Induced Skeletal Muscle Myoblast Damage through the Down-Regulation of Ceramide
• Pharmacological Characterization of Vasorelaxant Effects of BMS-180448, a Novel Cardioselective ATP-Sensitive Potassium Channel Opener, in Rat Aorta
• Inhibitory Effects of Docetaxel on Platelet-Derived Growth Factor (PDGF)-BB–Induced Proliferation of Vascular Smooth Muscle Cells Through Blocking PDGF-Receptor β Phosphorylation
• Antiplatelet and Antithrombotic Activities of NQ301,2-Chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone
• Inverse Relationship between Adipocyte Differentiation and Ceramide Level in 3T3-L1 Cells
• Antiplatelet Effect of 2-Chloro-3-(4-acetophenyl)-amino-1, 4-naphthoquinone(NQ301) : A Possible Mechanism through Inhibition of Intracellular Ca^Mobilization
• FUMONISIN-INDUCED ELEVATION OF FREE SPHINGANINE AND CELL CONFLUENCY ARE INVERSELY CORRELATED IN LLC-PK CELLS
• Inhibitory Effects of Docetaxel on Platelet-Derived Growth Factor (PDGF)-BB-Induced Proliferation of Vascular Smooth Muscle Cells Through Blocking PDGF-Receptor β Phosphorylation
• Clitocybin A, a Novel Isoindolinone, From the Mushroom Clitocybe aurantiaca, Inhibits Cell Proliferation Through G1 Phase Arrest by Regulating the PI3K/Akt Cascade in Vascular Smooth Muscle Cells
• JJK694, a Synthesized Obovatol Derivative, Inhibits Platelet Activation by Suppressing Cyclooxygenase and Lipoxygenase Activities

もっと見る 閉じる

スポンサーリンク