Antiplatelet and Antithrombotic Activities of NQ301,2-Chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone

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概要

• 論文の詳細を見る

• The antiplatelet and antithrombotic activities of a newly synthesized NQ301,2-chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone, were investigated on human platelet aggregation in vitro and rats ex vivo, and murine pulmonary thrombosis in vivo. NQ301 potently inhibited ADP-, collagen-, epinephrine- and calcium ionophore A23187-induced human platelet aggregation in a concentration-dependent manner in vitro. NQ301 significantly inhibited platelet aggregation in orally administered rats ex vivo. NQ301 prevented death due to pulmonary thrombosis in mice dose-dependently in vivo. NQ301 also showed significant prolongation of tail bleeding time in conscious mice. However, NQ301 did not alter such coagulation parameters as activated partial thromboplastin time, prothrombin time, and thrombin time in human plasma. These results suggest that NQ301 may be a promising antithrombotic agent, and the antithrombotic activity of NQ301 may be due to antiplatelet aggregation activity but not to in vitro anticoagulation.

• 公益社団法人日本薬学会の論文
• 1999-12-15

著者

• Yun Yeo-Pyo

  College of Pharmacy, Chungbuk National University

• Yun Yeo-pyo

  Coll. Of Pharmacy Chungbuk National Univ.

• Yun Yeo-pyo

  College Of Pharmacy Research Center For Bioresource And Health Chungbuk National University

• Yun Y‐p

  Chungbuk National Univ. Cheongju Kor

• Yun Yeo-pyo

  College Of Pharmacy Chungbuk National University

• Yuk Dong-yeon

  College Of Pharmacy Chungbuk National University

• Yoo Hwan-soo

  College Of Pharmacy Cbitrc Chungbuk National University

• Chung Kwang-hoe

  Cardiovascular Research Institute Yonsei University College Medicine

• Ko Myong-hwa

  College Of Pharmacy Chungbuk National University

• Ryu Chung-kyu

  College Of Phamacy Ewha Womans University

• KANG Won-Seek

  College of Pharmacy, Chungbuk National University

• KO Myoung-Wha

  College of Pharmacy, Chungbuk National University

• JOO Jeong-Chul

  College of Pharmacy, Chungbuk National University

• Kang Won-seek

  College Of Pharmacy Chungbuk National University

• Joo Jeong-chul

  College Of Pharmacy Chungbuk National University

• Yun Yeo-pyo

  College Of Pharmacy Cbitrc College Of Pharmacy And Medical Research Center Chungbuk National Univers

• Yoo Hwan-Soo

  College of Pharmacy and Medical Research Center, Chungbuk National University

• Yun Yeo-Pyo

  College of Pharmacy and Medical Research Center, Chungbuk National University

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