Novel Benzo[d]imidazole-2(3H)-thiones as Potent Inhibitors of the α-Melanocyte Stimulating Hormone Induced Melanogenesis in Melanoma B16 Cells
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概要
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In order to determine the optimum size of heterocycle of lead compound 1 (6-methyl-3-phenethyl-3,4-dihydro-1H-quinoline-2-thione; IC50=0.8 μM) for inhibition of melanogenesis, we have synthesized and evaluated some benzimdazole-2(3H)-thiones 5a—e. The preliminary bioassay has shown that the benzimdazole-2(3H)-thione motif of 5 is essential structural unit for their inhibitory activity. Among all thiones 5a—e, the compound 5d strongly inhibited the formation of melanin with IC50 value of 1.3 μM.
著者
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KIM Youngsoo
College of Pharmacy and Research Center for Bioresources and Health
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JUNG Sang-Hun
College of Pharmacy, Chungnam National University
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Jung Sang-hun
College Of Pharmacy Chungnam National University
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Kim Youngsoo
College Of Pharmacy & Research Center For Bioresource And Health Chungbuk National University
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BANG Seong-Cheol
College of Pharmacy, Chungnam National University
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Lee Jee-Hyun
College of Pharmacy and Institute of Drug Research and Development, Chungnam National University
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Thanigaimalai Pillaiyar
College of Pharmacy and Institute of Drug Research and Development, Chungnam National University
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Lee Ki-Cheul
College of Pharmacy and Institute of Drug Research and Development, Chungnam National University
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Kim Min-Seok
College of Pharmacy and Institute of Drug Research and Development, Chungnam National University
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Sharma Vinay
College of Pharmacy and Institute of Drug Research and Development, Chungnam National University
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Yun Cheong-Yong
College of Pharmacy, Chungbuk National University
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Roh Eunmiri
College of Pharmacy, Chungbuk National University
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Bang Seong-cheol
College Of Pharmacy Chungnam National University
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Roh Eunmiri
College Of Pharmacy Chungbuk National University
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Bang Seong-Cheol
College of Pharmacy and Institute of Drug Research and Development, Chungnam National University
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Jung Sang-Hun
College of Pharmacy and Institute of Drug Research and Development, Chungnam National University
関連論文
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