1-Methyl-2-undecyl-4(1H)-quinolone as an Irreversible and Selective Inhibitor of Type B Monoamine Oxidase
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概要
- 論文の詳細を見る
The inhibitory compound of monoaminc oxidase (MAO) activity was isolated from the CH_2Cl_2 fraction of the fructus of Evodia nitaecarpa and identified as 1-methyl-2-undecyl-4(lH)-quinolone (1). Compound 1 showed a selective inhibition of type B MAO (MAO-B) activity with the IC_50 value of 15.3 βM using a substrate kynuramine, but did not inhibit type A MAO (MAO-A) activity. The kinetic analysis using Lineweaver-Burk plots indicated that compound 1 competitively inhibited MAO-B activity with the K_1 value of 9.91 βM. The inhibition of MAO-B by compound 1 was found to be irreversible by dialysis of the incubation mixture. These results suggest that compound 1 is a potent irreversible inhibitor of MAO-B, and may regulate catecholamine content in the neurons.
- 公益社団法人日本薬学会の論文
- 2003-04-01
著者
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Hong Seong
College Of Pharmacy Chungbuk National University:division Of Biotechnology College Of Life Sciences
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Hong S
Chungbuk National Univ. Cheongju Kor
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Lee M
College Of Pharmacy Chungbuk National University
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Lee Seon
College Of Pharmacy Chungbuk National University
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Hwang Bang
College Of Pharmacy Chungbuk National University
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LEE Myung
College of Pharmacy, Chungbuk National University
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Lee M
Chungbuk National Univ. Chungbuk Kor
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RO Jai
College of Pharmacy, Chungbuk National University
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OH Gab
Samjin Pharm. Co. Ltd.
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LEE Kyong
College of Pharmacy, Chungbuk National University
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LEE Seon
Program for Collaborative Research in the Pharmaceutical Science and Department of Medicinal Chemist
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OH Gab
College of Pharmacy, Chunghuk National University
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CHOI Woo
Samjin Pharm. Co., LTD.
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Lee Myung
College Of Pharmacy Chungbuk National University
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Oh Gab
College Of Pharmacy Chunghuk National University
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Ro Jai
College Of Pharmacy Chungbuk National University
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Lee Kyong
College Of Pharmacy Chunghuk National University
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Hwang Bang
Coll. Of Pharmacy Chungbuk National Univ.
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Lee Myung
College Of Pharmacy And Research Center For Bioresource And Health Chungbuk National University
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Choi Woo
Samjin Pharm. Co. Ltd.
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