Anxiolytic-Like Effects of Ginsenosides on the Elevated Plus-Maze Model in Mice(Pharmacology)

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In a previous study, we reported that ginseng extract has anxiolytic-like effects in the elevated plus-maze model and that the ginseng saponin fraction plays an important role. This experiment was performed to investigate the anxiolytic-like effects of ginsenosides Rb_1, Rg_1, Rg_3-R, and Rg_3-S, and the Rg_5 and Rk mixture isolated from the ginseng saponin fraction in the elevated plus-maze. Furthermore, the anxiolytic-effects of Rb_1, Rg_1, Rg_3-R, Rg_3-S, and the Rg_5 and Rk mixture were compared with those of a well-known active anxiolytic drug (diazepam). The oral administration of ginsenoside Rb_1 significantly increased the number of open arm entries and the time spent on the open arm compared with those in the vehicle-treated group. Ginsenoside Rg_1 and the Rg_5 and Rk mixture also significantly increased the number of open arm entries and the time spent on the open arm. However, ginsenosides Rg_3-R and Rg_3-S did not increase the number of open arm entries or the time spent on the open arm. On the other hand, ginsenoside Rb_1 and the Rg_5 and Rk mixture decreased locomotor activity in a manner similar to diazepam. These data indicate that ginsenosides Rb_1, Rg_1, and the Rg_5 and Rk mixture have anxiolytic-like effects, but ginsenosides Rg_3-R and Rg_3-S do not in this model. We provide evidence that some gin-senosides may be useful for the treatment of anxiety.
公益社団法人日本薬学会の論文
2005-09-01