Resveratrol Oligomers from Vitis amurensis Attenuate β-Amyloid-Induced Oxidative Stress in PC12 Cells(Pharmacognosy)
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概要
- 論文の詳細を見る
Oxidative damage induced by β-amyloid (Aβ) is closely associated with the hallmark pathologies of Alzheimer's disease (AD) and may play a critical role in the development of AD. In this study, the protective effects of vitisin A and heyneanol A, resveratrol oligomers isolated from Vitis amurensis RUPR. (Vitaceae), against Aβ-induced oxidative cell death were investigated using rat pheochromocytoma (PC12) cells. Exposure of PC12 cells to the Aβ (20μM) for 24 h resulted in neuronal cell death, whereas pretreatment with vitisin A or heyneanol A at the concentration range of 5-50 μM reduced Aβ-induced cell death. In addition, Aβ-induced elevation of reactive oxygen species generation, the primary cause of Aβ-induced oxidative stress, was attenuated by treatment of vitisin A or heyneanol A (10, 25, 50 μM). Aβ-treated cells also displayed characteristic features of apoptosis such as induction of DNA fragmentation and caspase-3 activation, but vitisin A and heyneanol A (10, 50 μM) significantly suppressed these events. These results suggest that vitisin A and heyneanol A prevent Aβ-induced neurotoxicity through attenuating oxidative stress induced by Aβ, and may be useful as potential preventive or therapeutic agents for AD.
- 公益社団法人日本薬学会の論文
- 2007-06-01
著者
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Kim Hyun
College Of Pharmacy Kangwon National University
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Park Jeong
Res. Inst. Of Pharmaceutical Sciences Coll. Of Pharmacy Seoul National Univ.
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PARK Jeong
College of Pharmacy, Seoul National University
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BAEK Seung
College of Pharmacy, Seoul National University
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Kim Hyun
Dep. Of Food Sci. Jinju National Univ.
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Baek S
College Of Pharmacy Seoul National University
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Baek Seung
College Of Pharmacy Seoul National University
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Park J
College Of Pharmacy Seoul National University
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Park Jeong
College Of Pharmacy And Research Institute Of Pharmaceutical Sciences Seoul National University
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Piao Xiang
School Of Pharmaceutical Sciences Peking University
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Kwon Sung
College Of Pharmacy And Research Institute Of Pharmaceutical Sciences Seoul National University
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JANG Moon
College of Pharmacy, Seoul National University
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CHO Eun
College of Pharmacy, Seoul National University
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Cho Eun
College Of Pharmacy Seoul National University
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Jang Moon
College Of Pharmacy Seoul National University
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Kim Hyun
Univ. Toyama Toyama Jpn
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Kim H
Univ. Toyama Toyama Jpn
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Kim Hyun
College Of Pharmacy And Research Institute Of Drug Development Chonnam National University
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Kwon Sung
College Of Pharmacy Seoul National University
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Kim Hyun
College Of Electrical & Computer Engineering Chungbuk National University
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Baek Seung
College Of Information And Communications Korea University
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