Reduction of Cisplatin-Induced Nephrotoxicity by Ginsenosides Isolated from Processed Ginseng in Cultured Renal Tubular Cells(Pharmacognosy)

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概要

• 論文の詳細を見る

• Ginsenosides, the unique constituents and secondary metabolites of the Panax species, have been known to be the pharmacologically active ingredients of ginseng. Recently, our research group has developed a new processed ginseng, called Sun ginseng (SG), which has an increased amount of the red ginseng unique ginsenosides (RGUG). In our previous studies, this new processed ginseng reduced cisplatin-induced nephrotoxicity more than white ginseng in both in vitro and in vivo systems. In this study, we isolated and characterized active principles through activity-guided fractionation. Ginsenosides Rh_4 and Rk_3 significantly reduced the cisplatin-induced nephrotoxicity in LLC-PK_1 cells in a dose-dependent manner. The mechanisms of function and structure-activity relationships with other ginsenosides remain for further investigation.

• 公益社団法人日本薬学会の論文
• 2006-10-01

著者

• Park Jeong

  Res. Inst. Of Pharmaceutical Sciences Coll. Of Pharmacy Seoul National Univ.

• Park Jeong

  Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University

• BAEK Seung

  College of Pharmacy, Seoul National University

• Kim Hyun

  Dep. Of Food Sci. Jinju National Univ.

• Baek S

  College Of Pharmacy Seoul National University

• Baek Seung

  College Of Pharmacy Seoul National University

• Park J

  College Of Pharmacy Seoul National University

• Piao Xiang

  School Of Pharmaceutical Sciences Peking University

• KIM Hyun

  Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University

• BAEK Seung

  Research Institute of Pharmaceutical Sciences College of Pharmacy, Seoul National University

• LEE Un

  Research Institute of Pharmaceutical Sciences College of Pharmacy, Seoul National University

• Lee Un

  Research Institute Of Pharmaceutical Sciences College Of Pharmacy Seoul National University

• Kim Hee

  College Of Pharmacy Seoul National University

• Kim Hyun

  Research Institute Of Pharmaceutical Sciences College Of Pharmacy Seoul National University

• Kim Hyun

  Univ. Toyama Toyama Jpn

• Kim H

  Univ. Toyama Toyama Jpn

• Park Jeong

  Research Institute Of Pharmaceutical Sciences And College Of Pharmacy Seoul National University

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