Quercetin Attenuates Oxygen-Glucose Deprivation- and ExcitotoxinInduced Neurotoxicity in Primary Cortical Cell Cultures

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概要

• 論文の詳細を見る

• The possible role of quercetin, a naturally occurring plant flavonoid, in protecting against oxygen-glucose deprivation (OGD)-, excitotoxins-, and free radical-induced ncuronal injury in mouse cortical cell cultures was investigated. Pre- and co-treatment with quercetin (100μ_M) inhibited 50 min OGD-, 20 μ_M N-methyl-_D-aspartate (NMDA)-, and 50μ_M kainate-induced neurotoxicity by 36, 22, and 61%, respectively. Quercetin significantly ameliorated free radical-induced neuronal injury caused by buthionine sulfoximine, sodium nitroprusside, ZnCI_2, and FeCl_2. These results suggest that quercetin may contribute a neuroprotective action against ischemic neural injury, partially via antioxidant actions.

• 公益社団法人日本薬学会の論文
• 2003-04-01

著者

• PARK Jun

  Department of Plastic Surgery, College of Medicine, Inha University

• SHIN Taekyun

  Department of Veterinary Medicine, Graduate School, Cheju National University

• Park Jeong

  Res. Inst. Of Pharmaceutical Sciences Coll. Of Pharmacy Seoul National Univ.

• Kwon Hak

  Natural Products Laboratory College Of Pharmacy Sung Kyun Kwan University

• Kwon Y

  Kangwon National Univ. Chunchon Kor

• Kim H

  Neitmtoxicology Program. Department Of Pharmacy Kangwon National University

• Park Shin

  Department Of Bioscience & Biotechnology Institute Of Bioscience Sejong University

• Wie M

  Kangwon National Univ. Chunchon Kor

• Wie Myung

  Department Of Veterinary Medicine Kangwon National University

• Kwon Hak

  Graduate School Of East-west Medical Science Kyung Hee University

• Kim Hyoung

  Neitmtoxicology Program. Department Of Pharmacy Kangwon National University

• Kwon Myung

  Department Of Veterinary Medicine Kangwon National University

• Park Jun

  Department Of Microbiology Yonsei University College Of Medicine

• Park Shin

  Department Of Veterinary Medicine. Cheju National University

• Ha Hyun

  Department Of Veterinary Medicine. Cheju National University

• Kwon Myung

  Department Of Chemistry Chung-ang University

• Shin Taekyun

  Jeju National Univ. Jeju

• Shin Taekyun

  Department Of Veterinary Medicine Cheju National University

• KWON Yong

  Neitmtoxicology Program. Department of Pharmacy, Kangwon National University

• Ha Hyun

  Department Of Diagnostic Radiology Asan Medical Center University Of Ulsan College Of Medicine

• Shin T

  Jeju National Univ. Jeju

• Ha Hyun

  Department Of Chemistry And Chemistry Institute For Functional Materials Pusan National University

• Park Jun

  Department Of Internal Medicine Institute Of Gastroenterology Yonsei University College Of Medicine

• Park Jun

  Department Of Computer Science Hongik University

• Park Jun

  Department of Applied Physics, Kyung Hee University, Yongin 446-701, Korea

• Shin Taekyun

  Department of Veterinary Anatomy, College of Veterinary Medicine and Research Institute for Subtropical Agriculture and Biotechnology, Cheju National University

• SHIN Taekyun

  Department of Veterinary Anatomy, College of Veterinary Medicine and Applied Radiological Science Research Institute, Jeju National University

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