クリップによる圧迫損傷術を施したラット脊髄におけるカテプシンDの免疫組織化学的研究(解剖学)
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概要
- 論文の詳細を見る
脊髄損傷(SCI)時におけるカテプシンDの関与を検討するため,クリップによる圧迫損傷術をラットに施し,当該タンパク質の一過性発現を観察した.ウエスタンブロット解析の結果,SCI後4ならびに7日目において約31kDaの活性型カテプシンDが有意に増加したが,約44kDaの非活性型カテプシンDは相対的に変化しなかった.免疫染色によってカテプシンDは正常な脊髄のほとんどの神経細胞ならびに多くの神経膠細胞に恒常的に発現しており,SCI時にはCD68陽性の活性化マクロファージ/小膠細胞で特に強く観察された.これらの所見は,外傷による中枢神経系炎症時にマクロファージ/小膠細胞の貪食とライソゾーム活性化においてカテプシンDが重要な役割を果たすことを示唆する.
- 社団法人日本獣医学会の論文
- 2008-09-25
著者
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Kim Sung
韓国
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Na Ho-jeong
韓国
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SHIN Taekyun
Department of Veterinary Medicine, Graduate School, Cheju National University
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AHN Meejung
Department of Veterinary Medicine, Graduate School, Cheju National University
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KIM Heechul
Department of Veterinary Medicine, Graduate School, Cheju National University
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MOON Changjong
Department of Veterinary Medicine, College of Applied Life Science and Applied Radiological Science
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Kim Moon
Department Of Immunology School Of Medicine Kyungpook National University
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Kim H‐m
Kyung Hee Univ. Seoul Kor
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Kim Hyung
College Of Oriental Medicine Kyung Hee University
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Lee Y
Chungnam National Univ. Kor
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Kim Hyung-ryong
Dep. Of Dental Pharmacology And Wonkwang Biomaterial Implant Res. Inst. School Of Dentistry Wonkwang
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Kim H.
韓国
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LEE Tae-Ki
Department of Veterinary Anatomy, College of Veterinary Medicine and Research Institute for Subtropi
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LEE Yongduk
Department of Veterinary Anatomy, College of Veterinary Medicine and Research Institute for Subtropi
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SIM Ki-Bum
Department of Neurosurgery, College of Medicine, Cheju National University
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Kim Seungjoon
Department Of Veterinary Anatomy College Of Veterinary Medicine Chonnam National University
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Kim Sung-ho
Department Of Internal Medicine College Of Veterinary Medicine Seoul National University
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Sim Ki
Department Of Neurosurgery College Of Medicine Cheju National University
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Kim Moon
Department Of Psychiatry College Of Medicine Cheju National University
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Na Ho‐jeong
韓国
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Kim Moon
Department Of Dermatology And Cutaneous Biology Research Institute Yonsei University College Of Medi
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Sim Ki-bum
Department Of Neurosurgery Jeju National University School Of Medicine
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Kang Seong
Department Of Veterinary Surgery College Of Veterinary Medicine Chonnam National University
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Lee Tae-ki
Department Of Veterinary Anatomy College Of Veterinary Medicine And Research Institute For Subtropic
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Lee Youngho
Department Of Physiology College Of Medicine Yonsei University
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Lee Yongduk
Department Of Veterinary Medicine Cheju National University
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Ahn Meejung
Department Of Veterinary Anatomy College Of Veterinary Medicine And Research Institute For Subtropic
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Shin Taekyun
Jeju National Univ. Jeju
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Shin Taekyun
Department Of Veterinary Medicine Cheju National University
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Moon C
Department Of Veterinary Anatomy College Of Veterinary Medicine Chonnam National University
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Moon Changjong
Department Of Physiology University Of The Ryukyus School Of Medicine:department Of Veterinary Medic
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Jung H‐a
Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.
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Na Ho‐jeong
Dep. Of Pharmacology Coll. Of Oriental Medicine Inst. Of Oriental Medicine Kyung Hee Univ.
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Kim Hong‐joon
Department Of Veterinary Medicine College Of Life Sciences Research Institute For Subtropical Agricu
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Shin T
Jeju National Univ. Jeju
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Shin Taekyun
Department of Veterinary Anatomy, College of Veterinary Medicine and Research Institute for Subtropical Agriculture and Biotechnology, Cheju National University
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SHIN Taekyun
Department of Veterinary Anatomy, College of Veterinary Medicine and Applied Radiological Science Research Institute, Jeju National University
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