Study on the Ophthalmic Diseases in ICR Mice and BALB/c Mice
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概要
- 論文の詳細を見る
In pharmaceutical companies and research institutes, many toxicity tests are performed with laboratory animals. This study was performed to produce reference data for eye toxicity tests and to investigate the ophthalmic diseases of 408 ICR mice and 119 BALB/c mice, which are commonly used as subjects in toxicity tests. The experimental animals without clinical disorders were selected regardless of sex. The ophthalmic diseases were examined by using special ophthalmic instruments: direct ophthalmoscope, indirect ophthalmoscope, slit-lamp biomicroscope and focal illuminator. The most prevalent ocular variation within normal limits was hyaloid vessel remnant (ICR mice, 28.2%; BALB/c mice, 31.9%) and the incidence gradually decreased with age. The ocular diseases found in ICR mice were retinal degeneration (9.8%), corneal scar (4.2%), focal cataract (2.2%), anisocoria (1.2%), corneal ulcer (0.2%) and uveitis (0.2%). In BALB/c mice, corneal scar (9.2%), focal cataract (1.7%) and corneal ulcer (0.8%) were the ocular diseases found.
- 社団法人 日本実験動物学会の論文
- 2006-04-01
著者
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KIM Min
Department of Internal Medicine, Chonnam National University Hospital
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Jeong Seong
Department Of Preventive Dentistry School Of Dentistry Kyungpook National University
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Won Moo
Department Of Anatomy And Neurobiology College Of Medicine Hallym University:institute Of Neurodegen
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Yi Na
Department Of Veterinary Surgery And Ophthalmology College Of Veterinary Medicine Seoul National Uni
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Kim Min
Department Of Veterinary Surgery And Ophthalmology College Of Veterinary Medicine Seoul National Uni
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Suh Jun
Department Of Medical Genetics And Experimental Animal Center College Of Medicine Hallym University
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Park Jae
Department of Nuclear and Energy Engineering, Jeju National University
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Kim Min-su
Departments Of Surgery College Of Veterinary Medicine Seoul National University
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Jeong Seong
Department Of Veterinary Surgery College Of Veterinary Medicine Chungnam National University
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Won Moo
Department Of Anatomy College Of Medicine Hallym University
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Park Shin
Department Of Bioscience & Biotechnology Institute Of Bioscience Sejong University
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Park Shin
Department Of Veterinary Surgery And Ophthalmology College Of Veterinary Medicine Seoul National Uni
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Park Jae
Department Of Laboratory Animal Medicine College Of Veterinary Medicine Seoul National University
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Seo Kang
Department Of Veterinary Surgery And Ophthalmology College Of Veterinary Medicine Seoul National Uni
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Seo Kang-moon
Department Of Animal Surgery College Of Veterinary Medicine Kangwon National University
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Seo Kang
Surgery College Of Veterinary Medicine And School Of Agricultural Biotechnology Seoul National Unive
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Oh Yang
Department Of Medical Genetics And Experimental Animal Center College Of Medicine Hallym University
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JEONG Man
Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National U
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NAM Tchi
Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National U
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Jeong Seong
Department Of Veterinary Surgery College Of Veterinary Medicine Research Institute Of Veterinary Med
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Park Jae
Department Of Applied Bioscience And Biotechnology Faculty Of Life And Environmental Science
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Nam Tchi‐chou
Department Of Veterinary Surgery And Ophthalmology College Of Veterinary Medicine Seoul National Uni
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Nam T.-c.
韓国
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Jeong Man
Department Of Veterinary Surgery And Ophthalmology College Of Veterinary Medicine Seoul National Uni
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Jeong Seong
Department Of Chemical Engineering Sungkyunkwan University
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Kim Min
Department Of Chemical Engineering Cheju National University
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Park Jae
Department of Advanced Materials Science and Engineering, Sungkyunkwan University, Suwon, Kyunggi-do 440-746, South Korea
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Jeong Seong
Department of Ceramic Engineering, Yonsei University, Seoul 120-749, Korea
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Kim Min
Department of Applied Science, Korea Maritime University, Busan 606-791, Korea
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JEONG Man
Department of Veterinary Clinical Sciences, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151–742, Republic of Korea
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KIM Min
Department of Animal Science and Biotechnology, College of Agriculture and Life Science, Chungnam National University, Daejeon 305–764, Korea
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