Berberry Extract Reduces Neuronal Damage and N-Methyl-D-aspartate Receptor 1 Immunoreactivity in the Gerbil Hippocampus after Transient Forebrain Ischemia(Molecular and Cell Biology)
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概要
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In the present study, we studied the neuroprotective effects of berberry extract (BE) against ischemic damage and the temporal and spatial alterations of N-methyl-D-aspartate receptor type 1 (NR1) and NR2A/2B immunoreactivities in the gerbil hippocampal CA1 region after transient ischemia to examine anti-ischemic effects and its role in transient forebrain ischemia. In the vehicle-treated group, the percentage of cresyl violet positive pyramidal cells in the CA1 region was about 11.4% compared to the sham-operated group 4 d after ischemic insult. BE showed neuroprotective effects against ischemic damage after ischemia-reperfusion. In the BE-treated groups, about 60-75% of CA1 pyramidal cells were stained with cresyl violet 4 d after ischemic insult. We observed the percentage of berberine (7.45+0.85 mg/g in BE) by HPLC, which is active ingredient of BE. NR1 immunoreactivity in the stratum pyramidale of the CA1 region in the vehicle-treated group was significantly increased at 30 min after transient forebrain ischemia, while at this time the NR1 immunoreactivity in the BE-treated groups was significantly low compared to the vehicle-treated group. The pattern of NR2A/B immunoreactivity in the stratum pyramidale of the BE-treated group and its protein levels were similar to that in the vehicle-treated group after ischemic insult. These results suggest that BE has potent neuroprotective effects against ischemic damage via the reduction of NR1 activity.
- 公益社団法人日本薬学会の論文
- 2006-04-01
著者
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Kim Jong
School of Applied Chemical Engineering & The Institute for Catalysis Research, Chonnam National Univ
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HWANG In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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YOO Ki-Yeon
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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Won Moo
Department Of Anatomy And Neurobiology College Of Medicine Hallym University:institute Of Neurodegen
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Hwang In-koo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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KANG Tae-Cheon
Department of Anatomy, College of Medicine, Hallym University
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Kim Dong-woo
Central Research Institute Natural F&p Co. Ltd.
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Park Dong
Department Of Applied Biology And Chemistry Konkuk University
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Hwang In
韓国
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Kang Tae-cheon
Department Of Anatomy College Of Medicine Hallym University
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Yoo Ki-yeon
Department Of Anatomy College Of Medicine Hallym University
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Kim Jong
Department Of Surgery College Of Medicine Hallym University
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Kim Yo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Hwang In
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Lee Bong-hee
Institute For Systems Medicine Gil Medical Center Gachon University Of Medicine And Science
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Lee Bong-hee
韓国
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LIM Beong
Department of Life Science, Konkuk University
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Lim B
Department Of Life Science Konkuk University
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Lim Beong
Department Of Applied Biochemistry Konkuk University
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Lim Beong
Laboratory Of Food Science Department Of Food Science And Technology Faculty Of Agriculture 46-09 Ky
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Kim Sang
Faculty Of Dept. Of Electronic And Electric Engineering Postech
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Nam Young
Department Of Anatomy College Of Veterinary Medicine And School Of Agricultural Biotechnology Seoul
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Kim Dong‐woo
Natural F&p Co. Ltd Cheongwon Kor
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LEE Hyeon
School of Biotechnology and Bioengineering, Kangwon National University
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SEO Kangmoon
Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University
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Lim Beong
Department Of Life Science Konkuk University
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Seo Kangmoon
Department Of Veterinary Surgery College Of Veterinary Medicine Seoul National University
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Yoo Ki‐yeon
Hallym Univ. Chuncheon
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KIM Dong-Woo
Natural F&P Co., LTD
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Lee Hak
Division Of Wood Chemistry & Microbiology Korea Forest Research Institute
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Kim Yeong-in
Department Of Neurology Kangnam St. Mary's Hospital The Catholic University Of Korea
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Kim Sang
Faculty Of Marine Bioscience And Technology Kangnung National University
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Park Dong
Department Of Biochemistry Kon-kuk University
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Kim Sang
Faculty Of Applied Biology And Horticulture Sunchon National University
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Lee H
College Of Bioscience And Biotechnology Department Of Biomaterials Engineering Kangwon National Univ
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Yoo Ki-yeon
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Won M.H.
Department of Anatomy and Neurobiology, College of Medicine, Hallym University:Institute of Neurodegeneration and Neuroregeneration, Hallym University
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Hwang In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
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