種々月齢の特発性高血圧ラット歯状回におけるDoublecortin陽性神経前駆細胞 : SDラットとの比較について(解剖学)
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概要
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特発性高血圧ラット(SHR)は,血管障害性痴呆ならびに発作などの神経変性疾患のモデルとして医学研究に広く利用されている.本研究では,種々月齢のSHRとSDラット(SDR)歯状回顆粒細胞層下層における新生神経前駆細胞をdoublecortin(DCX)を指標として観察した(DCXは神経増殖ならびに分化のマーカーである).生後1ヶ月のSHRにおいてDCX免疫反応性,陽性細胞数,蛋白レベルはSDRのそれらより高かった.生後8ヶ月では,両系統のDCX免疫反応性,陽性細胞数,蛋白レベルは生後1ヶ月に比較して顕著に減少したが,依然としてSHRはSDRより高い値を示した.両系統のそれら値は加齢とともに減少し, SDRのDCX陽性細胞は生後12ケ月でほとんど見られなかった.これらの結果は,新たに産生された神経前駆細胞は生涯を通じてSDRよりSHRでより高いことを示す.
- 2008-04-25
著者
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HWANG In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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CHOI Jung
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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YOO Ki-Yeon
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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YI Sun
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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SEONG Je
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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LEE In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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YOON Yeo
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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WON Moo-Ho
Department of Anatomy and Neurobiology, College of Medicine, Hallym University
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Won Moo
Department Of Anatomy And Neurobiology College Of Medicine Hallym University:institute Of Neurodegen
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Seong Je
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Hwang In-koo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Hwang In
韓国
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CHUNG Dae
Department of Anatomy, College of Veterinary Medicine and School of Agricultural Biotechnology, Seou
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KIM Hyun-Jin
Life Science Research Institute, Unigen Inc.
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KIM Chung-Seop
Life Science Research Institute, Unigen Inc.
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DO Seon-Gil
Life Science Research Institute, Unigen Inc.
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Yoo Ki-yeon
Department Of Anatomy College Of Medicine Hallym University
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Kim Yo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Hwang In
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Lee I
Seoul National Univ. Seoul
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Lee I.
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Yoon Yeo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Yi Sun
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Chung Dae
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Choi Jung
Department Of Anatomy And Neurobiology College Of Medicine Hallym University
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Do Seon-gil
Life Science Research Institute Unigen Inc.
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Kim Hyun-jin
Life Science Research Institute Unigen Inc.
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Kim Chung-seop
Life Science Research Institute Unigen Inc.
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Nam Young
Department Of Anatomy College Of Veterinary Medicine And School Of Agricultural Biotechnology Seoul
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Yoo Ki‐yeon
Hallym Univ. Chuncheon
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Kim Yeong-in
Department Of Neurology Kangnam St. Mary's Hospital The Catholic University Of Korea
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Yi S
Anatomy College Of Veterinary Medicine Kyungpook National University
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Yoon Yeo-sung
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Lee In
Department Of Agronomy College Of Agriculture And Life Sciences Kyungpook National University
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Seong Je
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Yi Sun
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Lee In
Department Of Aerospace Engineering
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Yoo Ki-yeon
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Choi Jung
Department Of Agricultural Biotechnology Seoul National University
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Won M.H.
Department of Anatomy and Neurobiology, College of Medicine, Hallym University:Institute of Neurodegeneration and Neuroregeneration, Hallym University
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Hwang In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University
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WON Moo-Ho
Department of Anatomy and Neurobiology, and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University
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