Effects of Electroacupuncture at Zusanli and Baihui on Brain-Derived Neurotrophic Factor and Cyclic AMP Response Element-Binding Protein in the Hippocampal Dentate Gyrus
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概要
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Previously, we observed that electroacupuncture (EA) at ST36 (Zusanli) and GV20 (Baihui) enhanced cell proliferation and neuroblast differentiation in the rat dentate gyrus. In this study, we investigated the possible mechanisms of EA in this effect. For this, we applied EA at ST36 and GV20 of Wistar rats (13-week-old) once a day for 3 weeks. Application of EA at these acupoints significantly increased the number of phosphorylated cyclic AMP response element-binding protein (pCREB)-immunoreactive cells in the dentate gyrus. In addition, EA significantly increased the levels of brain-derived neurotrophic factor (BDNF) and pCREB protein in the dentate gyrus. The administration of K252a, an inhibitor of BDNF receptor, significantly reduced cell proliferation in the subgranular zone of dentate gyrus. These results suggest that EA significantly increased neuroblast plasticity via pCREB and BDNF activation in the dentate gyrus.
- 社団法人 日本獣医学会の論文
著者
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HWANG In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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YI Sun
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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SEONG Je
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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YOON Yeo
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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Seong Je
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Hwang In-koo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Chung Jin
Department of Veterinary Internal Medicine, College of Veterinary Medicine, and Research Institute f
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Yoo Dae
Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for V
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YOUN Hwa
Department of Veterinary Internal Medicine, College of Veterinary Medicine, and Research Institute f
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Hwang In
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Yoon Yeo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Youn Hwa
Department Of Dermatology Seoul National University College Of Medicine
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Yi Sun
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Chung Jin
Department Of Dermatology Seoul National University College Of Medicine
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Chung Jin
Department Of Biological Science Dong-a University
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