Identification of Acvr2a as a Th17 Cell-Specific Gene Induced during Th17 Differentiation
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概要
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IL-17-producing T lymphocytes have been found to comprise a distinct lineage of T helper cells (Th17 cells) that are major causes of autoimmune diseases such as EAE, RA, and IBD. In this study, we found that activin receptor type-2A (Acvr2a) is a gene induced during the differentiation of this effector cell lineage as compared with naïve T cells. The transcript of Acvr2a was not induced in Th1 and Th2 cells, and both TGF-β and IL-6 were required for the induction of Acvr2a. When the differentiation of Th17 cells was inhibited by all tarans retinoic acid (ATRA) which induces regulatory T cell (Treg) differentiation under Th17 differentiation conditions, expression of Acvr2a was also inhibited. Hence we propose that Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1, Th2, and Treg.
著者
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Kim Kwang
Division Of Basic & Applied Science National Cancer Center
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Chung Jin
Department Of Dermatology Seoul National University College Of Medicine
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Kim Dong
Division Of Electronic And Electrical Engineering Kyungnam University
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IHN Hyun-ju
Division of Applied Life Science, PMBBRC, Gyeongsang National University
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OH Sang-Seok
Division of Applied Life Science, PMBBRC, Gyeongsang National University
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MOON Chaerin
Division of Applied Life Science, PMBBRC, Gyeongsang National University
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SONG Hyunkeun
Department of Anatomy and Tumor Immunology, Inje University College of Medicine
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