Isoflavonoid from Viola hondoensis, Regulates the Expression of Matrix Metalloproteinase-1 in Human Skin Fibroblasts(Pharmacognosy)
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概要
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Long term and repeated exposure of ultraviolet (UV) light, a harmful environmental stress, on the skin often induces chronic skin diseases such as skin cancer as well as photoaging (premature skin aging), and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinases (MMPs) activities. Here we investigated the effect of 2′, 4′, 7-trihydroxyisoflavone isolated from the whole plants of Viola hondoensis (Violaceae) on the expression of MMPs in UV-irradiated human skin fibroblasts in vitro. 2′, 4′, 7-Trihydroxyisoflavone markedly reduced UV-induced MMP-1 expression, but not MMP-2, at the both mRNA and protein levels in a dose-dependent manner. Our report is the first description for the ability of 2′, 4′, 7-trihydroxyisoflavone to regulate MMP-1 expression specifically.
- 公益社団法人日本薬学会の論文
- 2005-05-01
著者
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Chung Jin
Department of Veterinary Internal Medicine, College of Veterinary Medicine, and Research Institute f
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MOON Hyung
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Ag
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KWAK Jong
College of Pharmacy, Sung Kyun Kwan University
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ZEE Ok
College of Pharmacy, Sung Kyun Kwan University
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LEE Joongku
Korea Research Institute of Bioscience and Biotechnology
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Chung Jin
Department Of Dermatology Seoul National University College Of Medicine
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Zee Ok
College Of Pharmacy Sung Kyun Kwan University
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Moon Hyung-in
Department Of Dermatology Seoul National University College Of Medicine And Institute Of Dermatologi
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Kwak Jong
College Of Pharmacy Sung Kyun Kwan University
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Moon Hyung
Department Of Dermatology Seoul National University College Of Medicine And Laboratory Of Cutaneous
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Moon Hyung
Department Of Dermatology Seoul National University College Of Medicine And Institute Of Dermatologi
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Chung Jin
Department Of Biological Science Dong-a University
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