Regulation Effect of 2',4',7-Trihydroxyisoflavone on the Expression of Matrix Metalloproteinase-1,2 in Ultraviolet-B Irradiated Primary Cultured Old Aged Human Skin Fibroblasts(Communications to the Editor)
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概要
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Long term and repeated exposure of UV light on the skin often induces chronic skin diseases such as skin cancer as well as photoaging, and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinase's (MMPs) activities. We investigated the effect of 2',4',7-trihydroxyisoflavone purified from the whole plants of Viola hondoensis W. BECKER et H BOISSIEU (Violaceae) on the expression of MMPs in UV-B irradiated old aged human skin fibroblasts. 2',4',7-trihydroxyisoflavone markedly reduced UV-induced MMP-1 expression, but not MMP-2, at the both mRNA and protein levels in a dose-dependent manner. Our report is the first description for the ability of 2',4',7-trihydroxyisoflavone to regulate MMP-1 expression from ultraviolet-B irradiated primary cultured old aged human skin fibroblasts.
- 公益社団法人日本薬学会の論文
- 2005-11-01
著者
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Chung Jin
Department of Veterinary Internal Medicine, College of Veterinary Medicine, and Research Institute f
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Chung Jin
韓国
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Chung Jin
Department Of Dermatology Seoul National University College Of Medicine Laboratory Of Cutaneous Agin
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MOON Hyung
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Ag
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KWAK Jong
College of Pharmacy, Sung Kyun Kwan University
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ZEE Ok
College of Pharmacy, Sung Kyun Kwan University
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Chung Jin
Department Of Dermatology Seoul National University College Of Medicine
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Zee Ok
College Of Pharmacy Sung Kyun Kwan University
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Moon Hyung
韓国
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Kwak Jong
College Of Pharmacy Sung Kyun Kwan University
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Moon Hyung
Department Of Dermatology Seoul National University College Of Medicine And Institute Of Dermatologi
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Chung Jin
Department Of Biological Science Dong-a University
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