Triterpenoid from Styrax japonica SIEB. et ZUCC, and Its Effects on the Expression of Matrix Metalloproteinases-1 and Type 1 Procollagen Caused by Ultraviolet Irradiated Cultured Primary Human Skin Fibroblasts(Pharmacognosy)
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概要
- 論文の詳細を見る
Long term and repeated exposure of ultraviolet light on the skin often induces chronic skin diseases such as skin cancer as well as photoaging, and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinase's (MMPs) activities. The methylene chloride soluble fraction of methanol extract from the stems of Styrax japonica. (Styracaceae) showed significant MMP-1 inhibition in primary human skin fibroblasts cause by ultraviolet irradiation. Four triterpenoids were isolated by column chromatography. Among them, Erythrodiol-3-acetate reduced of MMP-1 and induced of type 1 procollagen at the protein levels in a dose-dependent manner.
- 公益社団法人日本薬学会の論文
- 2005-10-01
著者
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KIM Mi
College of Oriental Medicine, Daegu Haany University
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Kim Mi
College Of Pharmacy Chosun University
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Chung Jin
Department Of Dermatology Seoul National University College Of Medicine
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Moon Hyung-in
Department Of Dermatology Seoul National University College Of Medicine And Institute Of Dermatologi
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Moon Hyung
Department Of Dermatology Seoul National University College Of Medicine And Institute Of Dermatologi
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Chung Jin
Department Of Dermatology Seoul National University College Of Medicine And Institute Of Dermatologi
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WOO Eun
College of Pharmacy, Chosun University
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Woo Eun
College Of Pharmacy Chosun University
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Kim Mi
College Of Oriental Medicine Daegu Haany University
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Chung Jin
Department Of Biological Science Dong-a University
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Kim Mi-Ran
College of Pharmacy, Chosun University
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Woo Eun-Ran
College of Pharmacy, Chosun University
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