Inulin Induces Dendritic Cells Apoptosis through the Caspase-Dependent Pathway and Mitochondrial Dysfunction
スポンサーリンク
概要
- 論文の詳細を見る
Dendritic cells are professional antigen-presenting cells that are responsible for initiating of the immune response. However, there are no reports on how the polysaccharides in an oral biofilm affect the viability of dendritic cells. Inulin, a fructooligossacharide, is one component of oral biofilm fructan that is used as an energy source by oral bacteria. In this study, we found that murine bone marrow derived dendritic cells were induced to undergo apoptosis after being treated with inulin in a dose-dependent manner, as determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), annexinV/propidium iodide (PI), and Hoechest staining methods. Inulin activated the apoptotic pathway, including caspase-9 and caspase-3, decreased the level of B-cell lymphoma 2 (Bcl-2) expression, increased the expression of the Bcl-2-associated X protein (Bax) protein and induced poly(ADP-ribose) polymerase (PARP) cleavage. These observations suggest that inulin induces the apoptosis of dendritic cells by altering the Bcl-2/Bax ratio through the caspase dependant pathway. These results indicated that high concentrations of inulin can cause apoptic cell death in murine bone marrow-derived dendritic cells.
著者
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Ryu Sung
Department Of Biochemistry Wonju College Of Medicine Yonsei University
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Jeong Myung
Heart Center Chonnam National University Hospital
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Ha Tae
Department Of Agricultural Chemistry Division Of Applied Life Science Gyeongsang National University
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Chung Jin
Department Of Dermatology Seoul National University College Of Medicine
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Lee Jun
Department Of Dermatology College Of Medicine The Catholic University Of Korea
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Kim Kwang
Department Of Anatomy Wonkwang University
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Yoon Young-Ok
Department of Periodontology, School of Dentistry, Pusan National University
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Yoon Taek
Heart Research Center of Chonnam National University Hospital
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Kim Hyung
Heart Research Center of Chonnam National University Hospital
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Chung Jin
Department Of Biological Science Dong-a University
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Lee Jun
Department of Biology, College of Natural Sciences, Chosun University
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Ryu Sung
Department of Surgery, Busan Paik Hospital, Inje University College of Medicine
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Kim Kwang
Department of Surgery, Busan Paik Hospital, Inje University College of Medicine
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Chung Jin
Department of Periodontology, School of Dentistry, Pusan National University
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Jeong Myung
Heart Research Center of Chonnam National University Hospital
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Ha Tae
Department of Surgery, Busan Paik Hospital, Inje University College of Medicine
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KIM Kwang
Department of Advanced Materials Engineering (Polymerics Program), Korea Advanced Institute of Science and Technology (KAIST)
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