Meso-dihydroguaiaretic Acid from Machilus thunbergii SIEB et ZUCC., and Its Effects on the Expression of Matrix Metalloproteinase-2,9 Cause by Ultraviolet Irradiated Cultured Human Keratinocyte Cells (HaCaT)(Communications to the Editor)
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概要
- 論文の詳細を見る
Ethanol and aqueous extracts of Machilus thunbergii used traditionally for the treatments a wide variety of diseases were screened in vitro for the matrix metalloproteinase (MMP)-9 inhibitor actions. Meso-dihydroguaiaretic acid from the stems bark of Machilus thunbergii showed significant MMP-9 inhibition in human keratinocyte cells cause by ultraviolet irradiation. Here we investigated the effect of meso-dihydroguaiaretic acid, which was isolated from Machilus thunbergii, on UV-induced premature skin aging. We studied the effect of meso-dihy-droguaiaretic acid on UV-induced MMP-9 expression in an immortalized human keratinocyte cell line, HaCaT, in vitro. Acute UV irradiation induced MMP-9 expression at both the mRNA and protein levels and meso-dihydroguaiaretic acid suppressed this UV-induced MMP-9 expression in a dose-dependent manner. Taken together, these results show that meso-dihydroguaiaretic acid can prevent the harmful effects of UV that lead to skin aging. Therefore, we suggest that meso-dihydroguaiaretic acid should be viewed as a potential therapeutic agent for preventing and/or treating premature skin aging.
- 公益社団法人日本薬学会の論文
- 2005-11-01
著者
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Chung Jin
Department of Veterinary Internal Medicine, College of Veterinary Medicine, and Research Institute f
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MOON Hyung
Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Ag
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Chung Jin
Department Of Dermatology Seoul National University College Of Medicine
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Moon Hyung
Department Of Dermatology Seoul National University College Of Medicine Laboratory Of Cutaneous Agin
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Chung Jin
Department Of Dermatology Seoul National University College Of Medicine Laboratory Of Cutaneous Agin
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Moon Hyung
Department Of Dermatology Seoul National University College Of Medicine And Institute Of Dermatologi
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Chung Jin
Department Of Biological Science Dong-a University
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