Relationship Between Microalbuminuria and Vulnerable Plaque Components in Patients With Acute Coronary Syndrome and With Diabetes Mellitus : Virtual Histology-Intravascular Ultrasound
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概要
- 論文の詳細を見る
Background: The purpose of the present study was to use virtual histology-intravascular ultrasound (VH-IVUS) to evaluate the relationship between microalbuminuria and plaque components in 920 patients. Methods and Results: Patients with albumin levels <30mg/g creatinine were defined as having normoalbuminuria (n=824), and those with albumin levels 30-300mg/g as having microalbuminuria (n=96). The microalbuminuria group contained more patients with acute coronary syndrome (ACS; 72% vs. 61%, P=0.018) and more patients with diabetes (53% vs. 26%, P<0.001). In ACS patients, %necrotic core (NC) volume was significantly greater in the microalbuminuria group compared with the normoalbuminuria group (19±10% vs. 15±9%, P=0.019), but not in patients with stable angina. In ACS patients, thin-cap fibroatheroma (TCFA) was observed more frequently in the microalbuminuria group (36% vs. 18%, P=0.008), and microalbuminuria was the independent predictor of TCFA (odds ratio [OR], 1.106; 95% confidence interval [CI]: 1.025-1.144, P=0.018). In diabetic patients, %NC volume was significantly greater in the microalbuminuria group compared with the normoalbuminuria group (20±9% vs. 16±10%, P=0.017), but not in non-diabetic patients. In diabetic patients, TCFA was observed more frequently in the microalbuminuria group (38% vs. 17%, P=0.002) and microalbuminuria was the independent predictor of TCFA (OR, 1.120; 95%CI: 1.038-1.204, P=0.012). Conclusions: Microalbuminuria was associated with a higher number of vulnerable plaque components in ACS and diabetic patients. More intensive medical therapy is needed to stabilize the vulnerable plaque if microalbuminuria is observed in diabetic ACS patients. (Circ J 2011; 75: 2893-2901)
- 社団法人 日本循環器学会の論文
- 2011-11-25
著者
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Ahn Young
The Heart Center Of Chonnam National University Hospital
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Kim Ju
The Heart Center Of Chonnam National University Hospital
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KIM Kye
Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute
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Choi Yun
Heart Center Of Chonnam National University Hospital Chonnam National University Research Institute
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Ko Young-guk
Division Of Cardiology Severance Cardiovascular Hospital Yonsei University College Of Medicine
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HONG Young
The Heart Center of Chonnam National University Hospital
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JEONG Myung
The Heart Center of Chonnam National University Hospital
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LEE Min
The Heart Center of Chonnam National University Hospital
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SIM Doo
The Heart Center of Chonnam National University Hospital
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YOON Nam
The Heart Center of Chonnam National University Hospital
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YOON Hyun
The Heart Center of Chonnam National University Hospital
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PARK Hyung
The Heart Center of Chonnam National University Hospital
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CHO Jeong
The Heart Center of Chonnam National University Hospital
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PARK Jong
The Heart Center of Chonnam National University Hospital
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KANG Jung
The Heart Center of Chonnam National University Hospital
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Kim Kun
The Heart Center Of Chonnam National University Hospital
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Jeong Myung
Yonsei University Wonju Hospital
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Ahmed Khurshid
Heart Center of Chonnam National University Hospital
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Kim Yong
Cardiovascular Research Institute Chonnam National University
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Jeong Yun
Lab Of Stem Cell And Tumor Biology College Of Veterinary Medicine Seoul National University
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Ahn Youngkeun
Department Of Cardiovascular Medicine Chonnam National University Medical School
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Jeong Myung
Heart Center Chonnam National University Hospital
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Ahn Youngkeun
Heart Center Chonnam National University Hospital
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Lee Kyung
Department Of Cardiovascular Medicine Chonnam National University Hospital Chonnam National Universi
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Choi Ji-yong
Division Of Cardiology Department Of Internal Medicine College Of Medicine Daegu Catholic University
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Park Kyung
Korea Atomic Energy Research Institute
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Kim Kyehun
Heart Center Chonnam National University Hospital
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Cho Jungsun
Heart Center Chonnam National University Hospital
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Jeong Myungho
Heart Center Chonnam National University Hospital
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Kim Ju
Heart Center Of Chonnam National University Hospital
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Hong Young
Heart Center Of Chonnam National University Hospital
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Cho Jeong
Heart Center Of Chonnam National University Hospital
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Choi Yun
Heart Center Of Chonnam National University Hospital
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Park Jong
Heart Center Of Chonnam National University Hospital
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Park Hyung
Heart Center Of Chonnam National University Hospital
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Sim Doo
Heart Center Of Chonnam National University Hospital
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Yoon Nam
Heart Center Of Chonnam National University Hospital
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Kang Jung
Heart Center Of Chonnam National University Hospital
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Yoon Hyun
Heart Center Of Chonnam National University Hospital
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Lee Min
Heart Center Of Chonnam National University Hospital
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Park Keun
Heart Center Of Chonnam National University Hospital
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Kim Yun-hyeon
Department Of Radiology Chonnam National University Hospital The Research Institute Of Medical Scien
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Kim Young
Department Of Radiology Chonnam National University Hospital The Research Institute Of Medical Scien
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Kim Yong
Department Of Radiology Chonnam National University Hospital The Research Institute Of Medical Scien
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Jeong Myung
Department Of Cardiovascular Medicine Chonnam National University Medical School
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SONG Jin
Heart Center of Chonnam National University Hospital
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KIM Dong
Heart Center of Chonnam National University Hospital
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LEE Ki
Heart Center of Chonnam National University Hospital
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Hong Youngjoon
Heart Center Chonnam National University Hospital
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Kim Kye
Heart Center of Chonnam National University Hospital, Cardiovascular Research Institute of Chonnam National University
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