Effect of Combination Therapy With Simvastatin and Carvedilol in Patients With Left Ventricular Dysfunction Complicated With Acute Myocardial Infarction Who Underwent Percutaneous Coronary Intervention
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概要
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Background This study assessed the effects of combination therapy with simvastatin and carvedilol on clinical outcome in patients with left ventricular (LV) dysfunction after acute myocardial infarction (AMI). Methods and Results The study retrospectively analyzed the data from 672 patients with LV dysfunction [LV ejection fraction (LVEF) <40%] complicated with AMI who underwent percutaneous coronary intervention (PCI). The patients were divided into 4 treatment groups: combination group (n=160), simvastatin only group (n=216), carvedilol only group (n=242), neither treatment group (n=54). At 6 months after PCI, the LVEF had improved most significantly in the combination group. During 1-year follow-up, cardiac death occurred most frequently in the neither treatment group compared with the other 3 groups (combination: 4%, simvastatin alone: 7%, carvedilol alone: 8%, neither: 17%, p<0.001 between neither treatment and other 3 groups). The results on major adverse cardiovascular events (MACE) showed that the combination of simvastatin and carvedilol was associated with a relative risk reduction of 53% (p<0.001), treatment with simvastatin alone with a relative risk reduction of 44% (p=0.001), and carvedilol alone with a relative risk reduction of 40% (p=0.003) compared with neither treatment. The independent predictors of 1-year MACE were neither treatment, elevated high sensitivity C-reactive protein (≥0.5 mg/dl), and old age (>70 years). Conclusion Combination therapy with simvastatin and carvedilol had a positive impact on the endpoints of cardiovascular death and MACE and seems to have an additive beneficial effect on these endpoints in patients with LV dysfunction complicated with AMI who underwent PCI.
- 社団法人日本循環器学会の論文
- 2006-09-20
著者
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Ahn Young
The Heart Center Of Chonnam National University Hospital
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Kim Ju
The Heart Center Of Chonnam National University Hospital
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HONG Young
The Heart Center of Chonnam National University Hospital
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JEONG Myung
The Heart Center of Chonnam National University Hospital
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YOON Nam
The Heart Center of Chonnam National University Hospital
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KIM Kye
The Heart Center of Chonnam National University Hospital
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PARK Hyung
The Heart Center of Chonnam National University Hospital
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AHN Youngkeun
The Heart Center of Chonnam National University Hospital
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CHO Jeong
The Heart Center of Chonnam National University Hospital
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PARK Jong
The Heart Center of Chonnam National University Hospital
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KANG Jung
The Heart Center of Chonnam National University Hospital
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Lee Sang
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Hong Seo
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Kim Kun
The Heart Center Of Chonnam National University Hospital
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Hong Seo
The Heart Center Ofchonnam National University Hospital Chonnam National University Research Institu
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Lee Sang
Chonbuk National University Research Institute of Medical Science
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Hur Seung
Keimyung University
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Jeong Myung
Yonsei University Wonju Hospital
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Hur Seung
Heart Center of Chonnam National University Hospital
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Kim Yong
Cardiovascular Research Institute Chonnam National University
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Jeong Yun
Lab Of Stem Cell And Tumor Biology College Of Veterinary Medicine Seoul National University
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Lee Sang
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Hwang Sun
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Yun Nam
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Jeong Myung
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Choi Ji-yong
Division Of Cardiology Department Of Internal Medicine College Of Medicine Daegu Catholic University
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Hur Seung-ho
Department Of Cardiology Keimyung University Dongsan Medical Center
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Park Jong
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Kang Jung
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Kim Kyehun
Heart Center Chonnam National University Hospital
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Cho Jungsun
Heart Center Chonnam National University Hospital
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Jeong Myung
Department Of Cardiovascular Medicine Chonnam National University Medical School
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