Relationship Between Peripheral Monocytosis and Nonrecovery of Left Ventricular Function in Patients With Left Ventricular Dysfunction Complicated With Acute Myocardial Infarction
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概要
- 論文の詳細を見る
Background Although ischemic heart failure is a major cause of mortality after acute myocardial infarction (AMI), the factors that may influence the nonrecovery of left ventricular function (LVF) after an AMI are still unclear. The aim of this study was to identify predictors of nonrecovery of LVF in patients with left ventricular (LV) dysfunction (defined as an echocardiographic ejection fraction (EF) <40%) complicated with AMI who undergo successful primary percutaneous coronary intervention (PCI). Methods and Results LVF recovery was defined as improvement of LVEF more than 10% compared with baseline LVEF at follow-up. One hundred and eight patients with LV dysfunction after AMI were divided into 2 groups according to the LVF recovery at follow-up: patients with LVF recovery (n=64) vs patients without LVF recovery (n=44). The follow-up LVEF was measured at 8±4 months after PCI. Patients without LVF recovery were older (76±13 years vs 59±14 years, p=0.023) and the baseline peak monocyte count, creatine kinase, and troponin I levels were significantly higher in patients without LVF recovery than in patients with LVF recovery. Delta LVEF (follow-up LVEF-baseline LVEF) correlated with baseline peak monocyte count (r=-0.417, p<0.001), baseline peak creatine kinase (r=-0.269, p=0.005), and baseline peak troponin I levels (r=-0.256, p=0.007). Multivariate analyses showed that baseline peak monocyte count and old age were the independent predictors of nonrecovery of LVF (hazard ratio; 3.38, 95% confidence interval (CI): 1.16-5.43, p=0.012, and hazard ratio; 2.38, 95% CI: 1.09-4.87, p=0.025, respectively). Conclusion Peripheral monocytosis is associated with nonrecovery of LVF in patients with LV dysfunction complicating an AMI who underwent successful primary PCI. These results suggest an important role of monocytes in the expansion of the infarct and the development of chronic ischemic heart failure after reperfusion therapy.
- 社団法人日本循環器学会の論文
- 2007-07-20
著者
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Ahn Young
The Heart Center Of Chonnam National University Hospital
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Kim Ju
The Heart Center Of Chonnam National University Hospital
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Moon Jae
The Heart Center Of Chonnam National University Hospital Cardiovascular Research Institute Of Chonna
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HONG Young
The Heart Center of Chonnam National University Hospital
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JEONG Myung
The Heart Center of Chonnam National University Hospital
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YOON Nam
The Heart Center of Chonnam National University Hospital
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KIM Kye
The Heart Center of Chonnam National University Hospital
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PARK Hyung
The Heart Center of Chonnam National University Hospital
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AHN Youngkeun
The Heart Center of Chonnam National University Hospital
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CHO Jeong
The Heart Center of Chonnam National University Hospital
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PARK Jong
The Heart Center of Chonnam National University Hospital
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KANG Jung
The Heart Center of Chonnam National University Hospital
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Lee Sang
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Hong Seo
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Kim Kun
The Heart Center Of Chonnam National University Hospital
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Hong Seo
The Heart Center Ofchonnam National University Hospital Chonnam National University Research Institu
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Lee Sang
Chonbuk National University Research Institute of Medical Science
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Jeong Myung
Yonsei University Wonju Hospital
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Kim Yong
Cardiovascular Research Institute Chonnam National University
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Jeong Yun
Lab Of Stem Cell And Tumor Biology College Of Veterinary Medicine Seoul National University
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Lee Sang
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Jeong Myung
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Choi Ji-yong
Division Of Cardiology Department Of Internal Medicine College Of Medicine Daegu Catholic University
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Park Jong
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Kang Jung
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Kim Kyehun
Heart Center Chonnam National University Hospital
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Cho Jungsun
Heart Center Chonnam National University Hospital
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Jeong Myung
Department Of Cardiovascular Medicine Chonnam National University Medical School
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Hong Youngjoon
Heart Center Chonnam National University Hospital
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