Inflammation and Delayed Endothelization With Overlapping Drug-Eluting Stents in a Porcine Model of In-Stent Restenosis
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概要
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Background This study evaluated the inflammatory reaction at the site of overlapping drug-eluting stents (DBS) in a porcine model of in-stent restenosis. Methods and Results Twenty bare metal stents (BMS) (group I; n=10), 20 sirolimus-eluting stents (SES) (group II: n=10), 20 paclitaxel-eluting stent (PES) (group III: n=10), and 10 PES and 10 SES (group IV: n=10) were overlapped in the left anterior descending coronary arteries of 40 pigs. Follow-up coronary angiography and histopathology were performed at 4 weeks after stenting. For the overlapped segments, the minimal luminal diameter at 4 weeks was smaller in group I than in the other groups (1.78±0.13mm, 2.79±0.09mm, 2.90±0.04mm, 2.80±0.07mm, respectively; p<0.001), and the neointimal area (5.51±0.58mm2, 2.38±0.53mm2, 2.07±0.37mm2, 2.39±0.58mm2, respectively; p<0.001) and area stenosis (68.74±4.02%, 27.79±4.73%, 23.66±3.24%, 27.63±±4.07%, respectively; p<0.001) were higher in group I than in the other groups; however, the inflammatory score was higher in group HI than in the other groups (1.80±0.42, 2.10±0.32, 2.90±0.31, 2.50±0.52, respectively; p<0.001) and the endothelization score was lower in group in than in the other groups (2.80±0.42, 2.30±0.67, 1.30±0.48, 2.10±0.74, respectively; p<0.001). Conclusion Compared with BMS, DES inhibit neointimal hyperplasia, but inflammation and poor endothelization occur at the site of overlapping stents.
- 社団法人日本循環器学会の論文
- 2008-02-20
著者
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Ahn Young
The Heart Center Of Chonnam National University Hospital
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Kim Ju
The Heart Center Of Chonnam National University Hospital
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Moon Jae
The Heart Center Of Chonnam National University Hospital Cardiovascular Research Institute Of Chonna
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HONG Young
The Heart Center of Chonnam National University Hospital
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JEONG Myung
The Heart Center of Chonnam National University Hospital
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AHN Youngkeun
The Heart Center of Chonnam National University Hospital
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CHO Jeong
The Heart Center of Chonnam National University Hospital
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KANG Jung
The Heart Center of Chonnam National University Hospital
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Jeong Myung
Yonsei University Wonju Hospital
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Lim Sang
The Cardiovascular Center Of Korea University Anam Hospital
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Kim Yong
Cardiovascular Research Institute Chonnam National University
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Jeong Yun
Lab Of Stem Cell And Tumor Biology College Of Veterinary Medicine Seoul National University
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Ahn Youngkeun
Department Of Cardiovascular Medicine Chonnam National University Medical School
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Jeong Myung
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Lim Do
The Cardiovascular Center Of Korea University Anam Hospital
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Hong Soon
The Cardiovascular Center of Korea University Anam Hospital
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Ahn Youngkeun
Heart Center Chonnam National University Hospital
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Choi Ji-yong
Division Of Cardiology Department Of Internal Medicine College Of Medicine Daegu Catholic University
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Kang Jung
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Cho Jungsun
Heart Center Chonnam National University Hospital
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Jeong Myung
Department Of Cardiovascular Medicine Chonnam National University Medical School
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Hong Youngjoon
Heart Center Chonnam National University Hospital
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