Long-Term Clinical Results and Predictors of Adverse Outcomes After Drug-Eluting Stent Implantation for Bifurcation Lesions in a Real-World Practice : The COBIS (Coronary Bifurcation Stenting) Registry
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概要
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Background: Limited data exists regarding long-term clinical results and predictors of adverse outcomes after drug-eluting stents (DES) implantation for coronary bifurcation lesions in a real-world practice. Methods and Results: A total of 1,691 non-left main bifurcation lesions with side branches ≥2.0mm in 1,668 patients undergoing DES implantation between January 2004 and June 2006 from 16 centers in Korea were evaluated. True bifurcation was found in 69.2% of lesions and 82.7% of lesions were treated with 1-stent technique. During follow-up (median 22 months), cardiac death occurred in 0.9%, myocardial infarction (MI) in 1.2%, target lesion revascularization (TLR) in 4.7% and stent thrombosis in 0.7% of patients. There was no significant difference in major adverse cardiac events (MACE: composite of cardiac death, MI and TLR) between the 1-stent and the 2-stent groups (6.1% vs 7.5%, P=0.36). Stent length in the main vessel (hazard ratio (HR) 1.02, 95% confidence interval (CI) 1.001-1.03, P=0.03), paclitaxel-eluting stent (HR 1.98, 95%CI 1.34-2.92, P=0.001) and kissing ballooning (HR 2.01, 95%CI 1.29-3.13, P=0.002) were independent predictors of MACE. Kissing ballooning increased the risk of MACE especially in the 1-stent group, but not in the 2-stent group. Conclusions: In this large real-world registry, overall outcomes after DES implantation in bifurcation lesions were favorable and similar between the 1-stent and 2-stent groups. (Circ J 2010; 74: 2322-2328)
- 2010-10-25
著者
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Kim Hyo-soo
韓国
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Kim Hyo-soo
Seoul National University Hospital
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Kang Hyun-jae
韓国
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Jang Yangsoo
Yonsei University Research Institute Of Science For Aging Yonsei University
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JEONG Myung
The Heart Center of Chonnam National University Hospital
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KIM Hyo-Soo
Jeju self-government province
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Choi Seung-hyuk
Division Of Cardiology Samsung Medical Center Sungkyunkwan University School Of Medicine
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Tahk Seung-jea
Ajou University
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Jeong Myung-ho
Chonnam National University Hospital
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Rha Seung
Korea University
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Yang Ju-Young
National Health Insurance Corporation IIsan Hospital
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Yang Jeong
Department Of Medicine Cardiac And Vascular Center Sungkyunkwan University School Of Medicine Samsun
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Seung Ki
Catholic University Hospital
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Seung Ki
Catholic University Seoul St. Mary's Hospital
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GWON Hyeon-Cheol
Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University Scho
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SONG Young
Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University Scho
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HAHN Joo-Yong
Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University Scho
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SEONG In-Whan
Chungnam National University Hospital
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YOON Jung
Wonju Christian Hospital
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PARK Seung-Jung
Ulsan University Asan Medical Center
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Yang Ju-young
National Health Insurance Corporation Ilsan Hospital
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Tahk Seung-jea
Ajou University Hospital
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Choi Sung-hyuk
Division Of Cardiology Department Of Medicine Samsung Medical Center Sungkyunkwan University School
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Park Seung-jung
Cardiovascular Center And Department Of Internal Medicine Seoul National University Hospital
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Song Young
Division Of Cardiology Department Of Medicine Samsung Medical Center Sungkyunkwan University School
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Kim Hyo-soo
Cardiovascular Center And Department Of Internal Medicine Seoul National University Hospital
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Gwon Hyeon-cheol
Division Of Cardiology Department Of Medicine Samsung Medical Center Sungkyunkwan University School
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Jang Yangsoo
Yonsei University Severance Hospital
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YOON Jung-Han
Wonju Christian Hospital
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Jeong Myung
Department Of Cardiovascular Medicine Chonnam National University Medical School
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Jang Yangsoo
Yonsei University Health System
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