Effect of Hypercholesterolemia on Macrophage Infiltration After Balloon Injury to Rabbit Iliac Artery
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概要
- 論文の詳細を見る
Both hypercholesterolemia and vascular injury have been reported to induce macrophage infiltration, but their combined effect and the mechanism by which hypercholesterolemia enhances the infiltration remain to be clarified in vivo. To evaluate the effect of hypercholesterolemia on macrophage infiltration after vascular injury, the iliac arteries of hypercholesterolemic(HC) and normocholesterolemic(NC) rabbits were examined 2h, 1 day, 3 days, 7 days, and 14 days after balloon injury using immunohistochemical staining for macrophages, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule(VCAM)-1. Nuclear factor kappa-B (NF-κB) activation was also evaluated in fresh frozen iliac arteries using the electrophoretic mobility shift assay method. The fundamental difference between HC and NC was the amount of macrophage infiltration seen in HC from 7 days after balloon injury. Two out of 4 HC iliac arteries on the 7th day, and 3 out of 4 HC iliac arteries on the 14th day were positively stained with ICAM-1 in regenerated endothelium and neointima, whereas there were no positively stained NC iliac arteries. Neither HC nor NC tissues showed positive staining with VCAM-1. NF-κB was activated in HC 7 and 14 days after balloon injury, but not in NC. In conclusion, in vivo hypercholesterolemia induces macrophage infiltration after balloon injury and it is mediated by increased NF-κB activation promoting ICAM-1 expression.
- 社団法人日本循環器学会の論文
- 2001-01-20
著者
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Park Kyung
Department Of Laboratory Medicine Seoul National University College Of Medicine:seoul National Unive
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Park Kyung-woo
韓国
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Kim H‐s
Seoul National University Hospital
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Kim Hyo-soo
韓国
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Kim Hyo-soo
Seoul National University Hospital
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Suh Jung-won
Seoul National University Bundang Hospital
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Park Keun-Ho
Seoul National University Hospital
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Oh Byung-Hee
Seoul National University Hospital
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Chae In-Ho
Department of Internal Medicine, Seoul National University College of Medicine
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Oh Byung-Hee
Department of Internal Medicine, Seoul National University College of Medicine
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Park Young-Bae
Department of Internal Medicine, Seoul National University College of Medicine
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Chae In-ho
Bundang Hospital College Of Medicine Seoul National University
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Kang Hyun-jae
韓国
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Kang H‐j
Seoul National University Hospital
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Oh B‐h
Seoul National University Hospital
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Oh Byung-hee
韓国
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Park Y‐b
Division Of Cardiology Department Of Internal Medicine Seoul National University College Of Medicine
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Song Jong-min
Seoul National University Bundang Hospital
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Chae In-ho
Department Of Internal Medicine Seoul National University College Of Medicine
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Park Keun-ho
Department Of Laboratory Medicine Seoul National University College Of Medicine:seoul National Unive
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Park Keun-ho
韓国
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KIM Hyo-Soo
Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital
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PARK Kyung-Woo
Jeju self-government province
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SUH Jung-Won
Jeju self-government province
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KIM Hyo-Soo
Jeju self-government province
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Lee Myoung-mook
Department of Internal Medicine
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Park Kyung
韓国
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Park Hyo
韓国
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Lee Myoung-mook
韓国
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Lee M‐m
Seoul National University Hospital
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Lee Myoung-mook
Division Of Cardiology Department Of Internal Medicine Seoul National University College Of Medicine
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Park Young-bae
Division Of Cardiology Department Of Internal Medicine College Of Medicine Seoul National University
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Song Jong-min
Department Of Internal Medicine Seoul National University College Of Medicine Heart Research Institu
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Chae In-ho
Seoul National University College Of Medicine Cardiovascular Center Seoul National University Bundan
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Oh Byung-hee
Division Of Cardiology Department Of Internal Medicine College Of Medicine Seoul National University
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Park Young
Division Of Cardiology Department Of Internal Medicine College Of Medicine Seoul National University
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Park Young-bae
Department Of Internal Medicine College Of Medicine Scoul National University
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Park Sun-Jung
Department of Internal Medicine, Seoul National University College of Medicine, Heart Research Insti
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PARK Seung-Jung
Ulsan University Asan Medical Center
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Park Sun-jung
Department Of Internal Medicine Seoul National University College Of Medicine Heart Research Institu
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Park Seung-jung
Cardiovascular Center And Department Of Internal Medicine Seoul National University Hospital
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Oh Byung-hee
Department Of Internal Medicine Seoul National University College Of Medicine
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Lee Myoung-mook
Department Of Internal Medicine Seoul National University College Of Medicine:cardiovascular Lab Cli
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Kim Hyo-soo
Cardiovascular Center And Department Of Internal Medicine Seoul National University Hospital
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Song Jong-min
Department Of Internal Medicine Seoul National University College Of Medicine
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Oh Byung-Hee
Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital
-
Song Jong-Min
Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center
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Park Young-Bae
Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital
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