Intracoronary Continuous Adenosine Infusion : A Novel and Effective Way of Inducing Maximal Hyperemia for Fractional Flow Reserve Measurement
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概要
- 論文の詳細を見る
Background Various methods are used to induce maximal hyperemia for physiologic studies, but the feasibility and efficacy of continuous intracoronary (IC) infusion of adenosine for measurement of fractional flow reserve (FFR) has not been well-defined. Methods and Results Patients with intermediate coronary artery stenosis were consecutively enrolled. In the phase I study, FFR was measured after 3 dosages of IC adenosine infusion (180, 240 and 300μg/min) in 30 patients. The phase II study was performed to compare the hyperemic efficacy of IC infusion (240μg/min) with IC bolus injection (40, 80μg) and intravenous (IV) infusion (140μg・kg^<-1>・min^<-1>) of adenosine in 20 patients. In the phase I study, no significant differences in FFR were observed with the 3 different doses of IC infusion (p=0.06). In the phase II study, FFR after an IC bolus injection (0.83±0.06) was significantly higher than with IV (0.79±0.07) or IC (0.78±0.09) infusion (p<0.01). However, no difference in FFR was observed for IC and IV infusions. Conclusion IC infusion of adenosine seems to be a safe and effective method of inducing maximal hyperemia for FFR measurement.
- 社団法人日本循環器学会の論文
- 2005-07-20
著者
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Park Young
Division of Cardiology, Department of Internal Medicine, College of Medicine, Seoul National Univers
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Koo Bon
Division Of Cardiology Department Of Internal Medicine Seoul National University College Of Medicine
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Choi Dong
Cardiovascular Center Bundang Seoul National University Hospital
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Kim Hyo
Seoul National University College Of Medicine
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Chae In
Cardiovascular Center Bundang Seoul National University Hospital
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Kim Cheol
Cardiovascular Center, Bundang Seoul National University Hospital
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Na Sang
Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medici
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Youn Tae
Cardiovascular Center, Bundang Seoul National University Hospital
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Kim Hyo
Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medici
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Lee Myoung
Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medici
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Oh Byung
Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medici
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Choi Yun
Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medici
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Tahk Seung
Ajou University School of Medicine
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Oh Byung
Seoul National University College Of Medicine
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Park Young
Seoul National University College Of Medicine
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Kim Cheol
Seoul National University College Of Medicine
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Youn Tae
Cardiovascular Center Bundang Seoul National University Hospital
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Choi Yun
Seoul National University College of Medicine
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Na Sang
Division Of Cardiology Department Of Internal Medicine Seoul National University College Of Medicine
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Kim Hyo
Division Of Cardiology Department Of Internal Medicine College Of Medicine Seoul National University
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Park Young
Division Of Cardiology Department Of Internal Medicine College Of Medicine Seoul National University
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Lee Myoung
Division Of Cardiology Department Of Internal Medicine Seoul National University College Of Medicine
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Choi Yun
Division Of Cardiology Department Of Internal Medicine College Of Medicine Seoul National University
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Koo Bon
Division Of Breast And Endocrine Surgery Hallym University Sacred Heart Hospital College Of Medicine
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