High Plasma Interleukin-6 Is Associated With Drug-Eluting Stent Thrombosis : Possible Role of Inflammatory Cytokines in the Development of Stent Thrombosis From the Korea Stent Thrombosis Registry
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概要
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Background: Inflammation might contribute to the development of stent thrombosis (ST). The association between inflammatory cytokine concentrations and drug-eluting ST were evaluated. Methods and Results: Among the 123 ST patients enrolled in the multicenter Korea Stent Thrombosis registry, plasma samples were available in 41 patients. The patients clinical characteristics and plasma concentrations of monocyte chemoattractant protein-1, tumor necrosis factor-alpha, and interleukin (IL)-6 were compared with 81 matched controls. Although the concentrations of 3 cytokines were higher in the ST group, they did not have significant differences. When divided into quartiles, the proportion of patients with the highest quartile of IL-6 was higher in the ST group than in the control group (44% vs. 16%, P=0.001), and the highest IL-6 quartile was an independent predictor of ST for both early (adjusted hazard ratio [HR] 6.96; 95% confidence interval [CI] 1.75-27.66) and late ST (adjusted HR 4.71; 95%CI 1.06-20.92). In addition, the highest IL-6 quartile was an independent predictor of ST in those on clopidogrel (adjusted HR 7.70; 95%CI 1.97-30.13) but not in those who were off clopidogrel. Conclusions: Highest IL-6 quartile was associated with ST, especially in clopidogrel users regardless of the time of ST, suggesting the involvement of inflammatory cytokines in ST. (Circ J 2011; 75: 1350-1357)
- 2011-05-25
著者
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Koo Bon-Kwon
Cardiovascular Center, Seoul National University Hospital
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Koo Bon
Heart Center Of Chonnam National University Hospital
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Park Kyung
Department Of Laboratory Medicine Seoul National University College Of Medicine:seoul National Unive
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Park Kyung-woo
韓国
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Kim H‐s
Seoul National University Hospital
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Kim Hyo-soo
韓国
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Kim Hyo-soo
Seoul National University Hospital
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Park Keun-Ho
Seoul National University Hospital
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Kim Hyung-Kwan
Seoul National University Hospital
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Chae In-ho
Bundang Hospital College Of Medicine Seoul National University
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Kang Hyun-jae
韓国
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Kang H‐j
Seoul National University Hospital
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Park Young-bae
韓国
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Park Y‐b
Division Of Cardiology Department Of Internal Medicine Seoul National University College Of Medicine
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Park Keun-ho
Department Of Laboratory Medicine Seoul National University College Of Medicine:seoul National Unive
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Park Keun-ho
韓国
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JEONG Myung
The Heart Center of Chonnam National University Hospital
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KIM Hyo-Soo
Jeju self-government province
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Park Kyung
韓国
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Park Hyo
韓国
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Tahk Seung-jea
Ajou University
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Jeong Myung-ho
Chonnam National University Hospital
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Park Young-bae
Division Of Cardiology Department Of Internal Medicine College Of Medicine Seoul National University
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Ahn Taehoon
Gachon University Gil Medical Center
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Jeong Myung
Yonsei University Wonju Hospital
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Chae In-ho
Seoul National University College Of Medicine Cardiovascular Center Seoul National University Bundan
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Park Young
Division Of Cardiology Department Of Internal Medicine College Of Medicine Seoul National University
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Gwon Hyeon-Cheol
Samsung Medical Center
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Yang Jeong
Department Of Medicine Cardiac And Vascular Center Sungkyunkwan University School Of Medicine Samsun
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Seung Ki
Catholic University Seoul St. Mary's Hospital
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PARK Seung-Jung
Ulsan University Asan Medical Center
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Yang Ju-young
National Health Insurance Corporation Ilsan Hospital
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Park Sun-jung
Department Of Internal Medicine Seoul National University College Of Medicine Heart Research Institu
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Tahk Seung-jea
Ajou University Hospital
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Park Seung-jung
Cardiovascular Center And Department Of Internal Medicine Seoul National University Hospital
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Park Kyung
Cardiovascular Center And Department Of Internal Medicine Seoul National University Hospital
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Kim Hyo-soo
Cardiovascular Center And Department Of Internal Medicine Seoul National University Hospital
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Gwon Hyeon-cheol
Division Of Cardiology Department Of Medicine Samsung Medical Center Sungkyunkwan University School
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Jang Yangsoo
Yonsei University Severance Hospital
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Park K‐w
Jeju Self-government Province
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Kang Hyun-jae
Cardiovascular Center Seoul National University Main Hospital
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Koo Bon-kwon
Cardiovascular Center Seoul National University Main Hospital
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Hwang Seok-jae
Cardiovascular Center Seoul National University Main Hospital
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Park Seung-jung
Asan Medical Center
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KWON Dong-A
Cardiovascular Center, Seoul National University Main Hospital
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SEUNG Ki
The Catholic University St. Mary's Hospital
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YOON Jung-Han
Wonju Christian Hospital
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JANG Yang-Soo
Yonsei University Severance Hospital
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Seung Ki
The Catholic University St. Mary's Hospital
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Kwon Dong-a
Cardiovascular Center Seoul National University Main Hospital
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Chae In-ho
Bundang Hospital
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Jeong Myung
Department Of Cardiovascular Medicine Chonnam National University Medical School
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Koo Bon-kwon
Cardiovascular Center Seoul National University Hospital
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